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Introduction: Gastrointestinal stromal tumors are uncommon mesenchymal tumors in the gastrointestinal tract. There is evidence reported of associated secondary neoplasms as synchronic and metachronous tumors. We aimed to describe the patients with synchronous and metachronous gastrointestinal stromal tumors in our reference center. Methods: Review of dataset of a prospectively collected database of 207 patients who underwent surgery for GIST management from 2008 to 2018. Results: 22 patients were included. Mean overall age was 69 (± 8,92) years. Male patients were 63.6%. Gastric was the most common location (68.1%, n=15), followed by small bowel (13.6%, n=3). Immunohistochemistry showed diffuse +CD117 in 100% of the cases. The synchronous tumors group included 11 cases and the most common type of tumor was gastric adenocarcinoma (n=2). For metachronous tumors, the primary localization was the prostate (45.5%, n=5). The most common type of metachronous tumor was prostatic adenocarcinoma (n=5). Conclusion: The stomach was the most common location for synchronous tumors and the prostate for metachronous tumors both being adenocarcinomas. The appearance of these tumors is not as uncommon as reported.

Background Inflammatory Bowel Disease (IBD) includes Ulcerative Colitis (UC) and Crohn Disease (CD). In the last decade, there have been introduced therapeutic changes that have revolutionised the pharmacologic and surgical management of patients with IBD. The incidence of UC and CD has been increasing in Latin America but the exact prevalence is unknown. Our objective is to describe the demographic characteristics, clinical and therapeutic aspects of the IBD in patients that have presented in the University Hospital Fundación Santa Fe de Bogotá (UH-FSFB), Colombia. Methods Retrospective Descriptive Cohort Study. Clinical histories, pathology reports, and endoscopic results from data base HI-ISIS of the UH-FSFB and medical data between January 1996 and February 2019 were recollected, stored in Excel and analysed using IBM SPSS Statistics Visor. Patients with diagnosis of IBD were included. Patients with incomplete clinical histories were excluded. Results From 398 patients included in this study, 72.1% had UC, 25.6% CD and 2.3% Indeterminate Colitis. The average age of diagnosis was 43.54 years (range: 12–91). In both patients with UC and CD there were smaller proportions of men than women (0.9:1 for UC and 0.7:1 for CD). Of the patients with UC, 46.3% had been hospitalised. 37.2% presented with proctitis, 23.8% left colitis and 39% with pancolitis. 13.5% had an asymptomatic clinical disease, 22.4% mild, 15.3% moderate, and 48.8% severe. 12.9% received biological therapy (BT). 24.3% of patients received a second line BT. Fifteen per cent required surgical interventions (SI), of which there were no mortalities. 27% who were receiving BT required SI. Of the patients with CD, 82.4% required hospitalisation. 43.1% had an ileal, 9.8% colonic, 39.2% ileal- colonic, 0% isolated upper digestive and 21.6% perianal compromise. 34.3% had non-stenosing behaviour, 49% stenosing and 16.7% penetrating. 44.1% of patients with CD received BT of which 40% required a second line BT. 55.9% required SI, of which 1 mortality was reported. 71.1% who were receiving BT required a SI. Conclusion Our study contributes to the epidemiology and integral management required by patients with IBD in our environment. More studies are recommended that replicate our methodology in the population with IBD in both Colombia and Latin America.

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