trabalho tem por objetivo verificar os níveis séricos hormonais de triiodotironina (T3) e tiroxina (T4) em ovelhas diagnosticadas com toxemia da prenhez (TP), bem como avaliar sua participação e reflexo neste tipo de transtorno metabólico. Foram analisadas as fichas clínicas de 24 ovelhas atendidas na Clínica de Bovinos, Campus Garanhuns/UFRPE, diagnosticadas com TP, no período de 2007 a 2012. Os animais foram submetidos ao exame clínico e ultrassonográfico, seguido de coleta de sangue e urina para exames laboratoriais. As principais alterações clínicas apresentadas pelos animais foram apatia, aumento da temperatura corporal, mucosas congestas, desidratação, edema dos membros, amaurose, taquicardia, inapetência a anorexia, diminuição da motilidade ou atonia ruminal. Vieram a óbito 50 % dos animais, destes 58,33% estavam hiperglicêmicos. A pesquisa de corpos cetônicos revelou um quadro de cetonúria. Quanto a glicemia, foram constatadas três condições nas ovelhas com TP. Os resultados laboratoriais revelaram valores elevados para ácidos graxos não-esterificados (AGNES) e β-hidroxibutirato (BHB). Enquanto que a média dos níveis séricos de T3 (3,21 nmol/L) e de T4 (69,16 nmol/L) nas ovelhas com TP foram consideradas como de baixas concentrações. Dessa forma, é possível concluir que a TP é caracterizada por alterações endócrinas que refletem o estado de balanço energético negativo em que as ovelhas acometidas se encontram. Palavras-chave: corpos cetônicos; distúrbio metabólico; hormônios; ovinos ABSTRACT:The aims of the present study were to determine serum levels of triiodothyronine (T3) and thyroxine (T4) in ewes diagnosed with pregnancy toxemia (PT) and evaluate the participation of these hormones in this type of metabolic disorder. Analyses were performed of the clinical cases of 24 ewes diagnosed with PT and treated at the Bovine Clinic of the University Federal Rural of Pernambuco, Campus Garanhuns, from 2007 to 2012. The animals were submitted to clinical and ultrasound exams. Blood and urine were collected for the laboratory exams. The main abnormalities were apathy, elevated body temperature, congested mucosa, dehydration, edema in the limbs, amaurosis, tachycardia, inappetence or anorexia and diminished ruminal motility. The mortality rate was 50%. Among the animals that died, 58.33% were hyperglycemic. The study of ketone bodies revealed ketonuria. Three conditions of glycemia were found in the ewes with PT. The laboratory findings revealed high levels of non-esterified fatty acids and β-hydroxybutyric acid. Serum levels of T3 (3.21 nmol/L) and T4 (69.16 nmol/L) were low. In conclusion, pregnancy toxemia in ewes is characterized by endocrine alterations that reflect a negative energy balance..
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