Background: Through splicing, squid express a conventional ADAR and a novel form with an extra RNA binding domain. Results: Chloride inhibits the ability of the conventional, but not the novel, ADAR to bind and edit RNA.
Conclusion:The extra RNA binding domain allows squid, an osmoconformer, to edit in a high salt environment. Significance: The ability of ADARs to bind RNA is a target for adaptation.
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