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Fecha de envío 19/05/21 Fecha de aprobación 30/05/21 Palabras claves Síndrome de sjogren Características clínicas ResumenEl síndrome de Sjögren es una enfermedad autoinmune sistémica caracterizada por la sequedad de mucosas y compromiso sistémico. El objetivo del presente estudio fue describir las características clínico epidemiológicas de los pacientes con Síndrome de Sjögren primario incluidos en la cohorte Psecopy que reúnan los criterios ACR/EULAR 2016 y que hayan acudido al Departamento de Reumatología del Hospital de Clínicas de San Lorenzo. Resultados: Se incluyeron 33 pacientes con Síndrome de Sjögren primario. De los cuales 31 (93,93%) pertenecían al género femenino y 2 (6,01%) al género masculino. Con una edad promedio al momento del diagnóstico de Sjögren primario de 46,12 años. Y un tiempo de duración de la enfermedad con una media de 2,10 años. Las comorbilidades más frecuentemente asociadas fueron la hipertensión arterial (21,21%) seguido del hipotiroidismo (18,18%). A estos pacientes se les realizó la biopsia salival por no cumplir criterios, en el 12,12 % de los pacientes según criterios de Chisholm y Mason, donde se encontró un focus score predominante de 3. En relación al ESSDAI se encontró un compromiso articular en 51,51 %, glandular en el 54,54 %, articular en 51,51%, pulmonar, linfadenopatía y dominio biológico en un 12,12%, hematológico y dominio constitucional en un 9,09%, cutáneo y renal en un 6,06%, sistema nervioso central y periférico en un 3,03%. Se destaca también la baja actividad de la enfermedad en un 63,63%, moderada actividad en un 21,21% y alta actividad en un 15,15% según la escala de ESSDAI. No se encontraron neoplasias. Epidemiological and clinical profile of patients withSjögren's Syndrome of the Rheumatology Department of the Hospital de Clínicas. Psecopy Project. Preliminary data.

Background:The mechanism of increased cardiovascular risk in RA is not well understood and is independent of traditional CV risk factors. Intima-media thickness of the common carotid wall measured by ultrasonogram is a safe and useful biomarker of early stage atherosclerosis that correlates with coronary involvement; and it correlates with severity and duration of disease. Several studies have shown a relationship between inflammation markers, endothelial dysfunction markers, and carotid involvement. (1)Objectives:To determine the presence of inflammation biomarkers and its relationship with subclinical atherosclerosis measured by carotid ultrasound, and with the clinical characteristics in patients with established Rheumatoid Arthritis (RA)Methods:Descriptive, cross sectional, prospective study, in a Paraguayan cohort of patients with RA meeting ACR/EULAR2010 criteria. This study had two phases: the first one, included a standardized questionnaire according to the variables included in the Cardiovascular Risk project (PINV15-0346), from the National Sciences and Technology Council (CONACYT), and physical examination; the second one included laboratory sample collection performed by a specialized laboratory for serum biomarkers measurement for cardiovascular risk prediction (i.e endothelin, alpha-TNF, E-selectin, homocysteine, apolipoprotein, fibrinogen, and high sensitivity-CRP levels) and carotid ultrasound evaluation by a trained specialist, to evaluate subclinical atherosclerosis. Subclinical atherosclerosis was defined as carotid intima-media thickness (CIMT) >0,9mm and/or presence of carotid plaques. All patients signed informed consent. SPSS 23rd version was used for data analysis. Quantitative variables were presented as means and qualitative as frequencies. Chi square test was performed for comparisons between dichotomous variables and t Student for continuous, and p ≤ 0.05 for statistical significance.Results:100 patients were included, 87% were women, mean disease duration 130.9±102.64 months, 77% were RF positive, and 84.4% were ACPA positive, 43.4% had bone erosions, mean ESR-DAS28 was 3,42±1,1; 30% had remission criteria. 39% had extra-articular manifestations.Elevated serum biomarkers were found: fibrinogen >400 mg/dL 88.2%, high sensitivity-CRP (hs-CRP) >5mg/dL 42.9%, endothelin >2 ng/mL 20%, alpha-TNF >15,6 pg/mL 13.1%, E-selectin >79,2 ng/mL 6%. 25.3% had CIMT >0,9 mm and mean CIMT was 0.68±0.25mm. 27.14% had carotid plaques. Patients with CIMT>1mm had higher frequency of family history of arterial hypertension (p=0.006), greater mean disease duration (p=0.0007), hip circumference (p=0.014), blood pressure (SBP p=0.038, DBP p=0.027), HAQ levels (p=0,019) and hs-CRP levels (p=0.013), also lower mean height (p=0,04); while carotid plaques were related to higher homocysteine (p=0.026) and hs-CRP levels (p=0.024).Conclusion:A considerable percentage of patients had subclinical atherosclerosis. Patients with CIMT>0,9mm had a longer disease duration, higher HAQ levels, hip circumference, as well as higher BP. High levels of hs-CRP were more frequently related to the presence of subclinical atherosclerosisReferences:[1]Aday, A. targeting residual inflammatory risk: a shifting paradigm for atherosclerotic disease. Frontiers in cardiovascular medicine. 2019. 6:16.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403155/pdf/fcvm-06-00016.pdfDisclosure of Interests:None declared

Background:Metabolic syndrome (MS) is associated with increased abdominal adipose tissue and production of inflammatory cytokines. Patients with MS are at increased risk for developing cardiovascular disease and diabetes mellitus, which are among the leading causes of death in chronic rheumatic diseases.Objectives:To characterize patients with rheumatic disease and MS and its association with inflammatory markers.Methods:Descriptive, cross sectional, prospective study, in 3 Paraguayan cohorts of patients with rheumatoid arthritis (RA), systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). This study had two phases: the first one, included a standardized questionnaire according to the variables included in the Cardiovascular Risk project (PINV15-0346), from the Consejo Nacional de Ciencias y Tecnología (CONACYT), and physical examination; the second one included laboratory sample collection performed by a specialized laboratory for serum biomarkers measurement for cardiovascular risk prediction (i.e endothelin, alpha-TNF, E-selectin, t-PA, VCAM, PAI-1 and high sensitivity-CRP levels). MS patients were categorized according to 2007 ALAD criteria. All patients signed informed consent. SPSS Statistics v23 was used for data analysis. Quantitative variables were presented as means and qualitative variables as frequencies. Chi square test was performed for comparisons between dichotomous variables. A p value ≤ 0.05 was used for statistical significance.Results:We included a total of 253 patients, 100 with RA, 100 with SLE and 52 with SSc. Metabolic syndrome was found in 23,58% (50/212). There was no significant difference in MS prevalence between diseases, but there was a higher frequency of increased abdominal circumference in RA and low HDL in SLE. Frequencies for different features of MS in RA, SLE and SSc are detailed in table 1.Table 1.Frequencies of MS component in SLE, SSc and RA.SLESScRAphsCRP23,52% (16/68)26,31% (10/38)42,85% (36/84)0,027E-Selectin5,88% (4/68)21,05% (8/38)5,95% (5/84)0,014t-PA0% (0/68)2,63% (1/38)5,95% (5/84)0,111VCAM20,58% (14/68)8,1% (3/37)0% (0/83)0,000TNF-α7,35% (5/68)18,42% (7/38)13,09% (11/84)0,229Endotelin20,58% (14/68)31,57% (12/38)19,75% (16/81)0,192PAI-111,36% (5/44)0% (0/38)0% (0/83)0,002Table 2.Frequency of high serum inflammatory biomarkers in SLE, RA and SSc.SLESScRApAbdominal circumference criteria43,4% (43/99)46,66% (21/46)64% (64/100)0,009Hypertension criteria67% (67/100)67,3% (35/52)55% (55/100)0,152HDL criteria55,22% (37/67)52,63% (20/38)16,12% (15/93)0,000TAG criteria22,38% (15/67)28,94% (11/38)22,58% (21/93)0,703Glycemia criteria7,69% (4/52)13,15% (5/38)25,67% (19/74)0,114Metabolic Syndrome24,35% (19/78)25% (9/36)22,44% (22/98)0,934Regarding inflammatory biomarkers, there was a significant difference between biomarkers elevated in each disease: hsCRP was found more frequently in RA, E-Selectin in SSc and VCAM and PAI-1 were more prevalent in SLE.Conclusion:We found a similar frequency of metabolic syndrome in our cohorts of RA, SSc and SLE Paraguayan patients but they had a different clinical and serological profile, suggesting that the pathways leading to metabolic syndrome are dissimilar in each disease. We need more studies to confirm this hypothesis.Disclosure of Interests:None declared

Fecha de envío 15/10/20 Fecha de aprobación 30/10/20 Palabras clave Ecografía, espondiloartritis ResumenIntroducción: La entesis es el órgano diana de la inflamación en las espondiloartritis (EspA) siendo clave en su fisiopatogenia. La ecografía está emergiendo como la técnica de preferencia para la detección de entesitis. Se realizó este estudio a fin de describir las características ecográficas del compromiso de las entesis en pacientes con espondiloartritis. materiales y métodos: Se evaluaron 20 pacientes con diagnóstico de EspA que acudieron al Hospital de Clínicas. Se investigaron variables clínicas y demográficas y posteriormente exploración ecográfica en 12 sitios de entesis hallándose los índices GUESS (Glasgow Enthesitis Scoring System) y MASEI (Madrid Sonographic Enthesitis Index) y posterior correlación de las variables ecográficas con las clínicas. Resultados: Los promedios de los índices BASDAI, ASDAS y BASFI fueron 4,05, 2,35, 3,56 respectivamente. De las 240 entesis evaluadas 35 (14,5%) presentaban dolor a la evaluación clínica. Se halló engrosamiento de tendón o ligamento en 42,5% de las entesis, calcificaciones en 24,1%, erosiones en 10,8%, y señal PD en 1,25%. El índice GUESS medio fue de 8,45 y el MASEI medio 15,2. No se encontró relación entre índices ecográficos e índices de BASDAI, ASDAS o BASFI. No se halló diferencia significativa entre los Índices GUESS y MASEI con los diferentes tipos de EspA, edad, tiempo de evolución ni tipo de tratamiento. El sexo masculino y el compromiso axial se asociaron a mayor índice GUESS y MASEI. Conclusión: Se encontró una pobre correlación entre la presencia de síntomas de entesitis y los hallazgos ecográficos. Los índices ecográficos MASEI y GUESS, no se correlacionaron con los índices de actividad de la enfermedad. Los valores de los índices MASEI y GUESS se relacionaron con el sexo masculino y el compromiso predominantemente axial en pacientes con EspA. Se halló una muy baja afectación inflamatoria aguda mediante detección de señal power doppler. ultrasonographic evaluation of enthesis involvement in patients with spondyloarthritis