Background A local increase in angiotensin 2 after inactivation of angiotensin-converting enzyme 2 by SARS-CoV-2 may induce a redox imbalance in alveolar epithelium cells, causing apoptosis, increased inflammation and, consequently, impaired gas exchange. We hypothesized that N-acetylcysteine (NAC) administration could restore this redox homeostasis and suppress unfavorable evolution in Covid-19 patients. Objective To determine whether NAC in high doses can avoid respiratory failure in patients with Covid-19. Methods It was a double-blind, randomized, placebo-controlled, unicentric trial, conducted at the Emergency Department of Hospital das Clínicas, São Paulo, Brazil. We enrolled 135 patients with severe Covid-19 (confirmed or suspected), with an oxyhemoglobin saturation of less than 94% or respiratory rate higher than 24 breaths/min. Patients were randomized to receive NAC 21 g (approximately 300 mg/kg) for 20 hours, or dextrose 5%. Primary endpoint was the need for mechanical ventilation. Secondary endpoints were time of mechanical ventilation, admission to ICU, time in ICU, and mortality. Results Baseline characteristics were very similar in the two groups, with no significant difference in age, sex, comorbidities, medicines taken, and disease severity. Also, groups were similar in laboratory tests and chest CT scan findings. Sixteen patients (23.9%) in the Placebo group were submitted to endotracheal intubation and mechanical ventilation, compared to 14 patients (20.6%) in the NAC group (p=0.675). No difference was observed in secondary endpoints. Conclusion Administration of NAC in high doses did not affect the evolution of severe Covid-19.

The human lens capsule thickness is at its maximum at the anterior midperiphery, which appears to be located central to the zonular insertion. It increases with age, especially at the anterior pole, while the midperipheral zone stabilizes or slightly decreases after the seventh decade. The anterior zonular insertion is actually related to a local pre-equatorial thinning, which remains unchanged with age. There was no posterior peripheral thickening, except in a few younger patients, with a modest relative maximum roughly at the equator. From here, the posterior capsule becomes progressively thinner and also diminishes with age, except for the thinnest, but stable posterior pole.

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In a previous work, we have shown that the null result of the MichelsonMorley experiment in vacuum is deeply connected with the notion of time. The same is true for the postulate of constancy of the two-way speed of light in vacuum in all frames independently of the state of motion of the emitting body. The argumentation formerly given is very general and has to be true not only within Special Relativity and its "equivalence" of all inertial frames, but as well as in Lorentz-Poincaré scenario of a preferred reference frame. This paper is the second of a trilogy intending to revisit the foundations of Special Relativity, and addresses the question of the constancy of the one-way speed of light and of the differences and similarities between both scenarios. Although they manifestly differ in philosophy, it is debated why and how the assumption of a "special system of reference experimentally inaccessible" is indeed compatible with Einstein's Special Relativity, as beautifully outlined and discussed by Bell [Speakable and Unspeakable in Quantum Mechanics (Cambridge University Press, Cambridge, 1988)]. This rather trivial statement is still astonishing nowadays to a big majority of scientists. The purpose of this work is to bring such assertion into perspective, widening the somewhat narrow view of Special Relativity often presented in textbooks and scientific papers.