Ever since Linus Pauling published his studies, the effects of vitamin C have been surrounded by contradictory results. This may be because its effects depend on a number of factors such as the redox state of the body, the dose used, and also on the tissue metabolism. This review deals with vitamin C pharmacokinetics and its participation in neurophysiological processes, as well as its role in the maintenance of redox balance. The distribution and the concentration of vitamin C in the organs depend on the ascorbate requirements of each and on the tissue distribution of sodium-dependent vitamin C transporter 1 and 2 (SVCT1 and SVCT2). This determines the specific distribution pattern of vitamin C in the body. Vitamin C is involved in the physiology of the nervous system, including the support and the structure of the neurons, the processes of differentiation, maturation, and neuronal survival; the synthesis of catecholamine, and the modulation of neurotransmission. This antioxidant interacts with self-recycling mechanisms, including its participation in the endogenous antioxidant system. We conclude that the pharmacokinetic properties of ascorbate are related to the redox state and its functions and effects in tissues.

Objective:To analyze the perioperative and long-term outcomes of patients undergoing LT due to BDI in a tertiary care center.Background:BDI is associated with significant morbidity and long-term impact on quality of life. LT represents the only possibility of a cure in patients with BDI who develop SBC.Methods:Retrospective cohort study from a prospective LT database. Between 2008 and 2019, patients with SBC due to BDI after cholecystectomy and requiring LT were identified. Perioperative and long-term outcomes were analyzed.Results:Among 354 LT, 12 patients underwent LT to treat post-cholecystectomy BDI and accounted for 3.4% of all LT. The median time from BDI to SBC diagnosis was 9.3 years (2.4–14). The mean time from SBC to inclusion on the waitlist was 2.4years (± 2.2). Postoperative complications occurred in 11 patients (91.6%); mainly infectious (9/12 patients, 75%), followed by renal complications (4/12 patients, 33.3%). Only 2 patients developed major complications, which were the patients who died, resulting in a 90-day mortality of 16.7%. After a mean follow-up of 40.3 months (± 42.2) survival at 1, 3, and 5 years was 83%.Conclusions:Although BDI is an unusual indication for LT worldwide, it accounted for 3.4% of all LT in our center. Although postoperative mortality remains high, LT is the only possibility of a cure, with acceptable long-term outcomes. Early referral to a tertiary care center is essential to avoid long-term complications of BDI, such as SBC.

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Los tumores de la glándula pancreática se caracterizan en general por su diagnóstico tardío y mal pronóstico. Se pueden clasificar en tumores endocrinos, exocrinos, quísticos, ampulares y periampulares. Las lesiones quísticas del páncreas, aunque se cree que son raras, pueden estar presentes hasta en un 25% de los pacientes basándose en estudios de autopsia, y hasta un 15% de los pacientes basándose en estudios de imágenes transversales. Los tumores quísticos mucinosos ocupan entre el 10% y 40% de los tumores quísticos del páncreas. La lesión compromete predominantemente a mujeres en la quinta década de la vida. Poseen entre 10 a 20% de posibilidades de malignizarse. En el siguiente reporte se presenta una serie de casos clínicos de pacientes diagnosticados con tumor quístico mucinoso y tratados en el Instituto Nacional Ciencias Médicas y Nutrición Salador Zubirán. (INCMNSZ). LUXMÉDICA, AÑO 14, NÚMERO 41, MAYO-AGOSTO 2019, PP 67-74.