Molluscum contagiosum (MC) is a self-limited infectious dermatosis, frequent in pediatric population, sexually active adults, and immunocompromised individuals. It is caused by molluscum contagiosum virus (MCV) which is a virus of the Poxviridae family. MCV is transmitted mainly by direct contact with infected skin, which can be sexual, non-sexual, or autoinoculation. Clinically, MC presents as firm rounded papules, pink or skin-colored, with a shiny and umbilicated surface. The duration of the lesions is variable, but in most cases, they are self-limited in a period of 6-9 months. The skin lesions may vary in size, shape, and location, which is more frequent in immunosuppressed patients, and could present complications such as eczema and bacterial superinfection. The diagnosis is based on clinical findings. A useful clinical tool is dermoscopy. If the diagnostic doubt persists, confocal microscopy or skin biopsy could be performed. The need for active treatment for MC is controversial; however, there is a consensus that it should be indicated in cases of extensive disease, associated with complications or aesthetic complaints. There are several treatment modalities which include mechanical, chemical, immunomodulatory, and antivirals. The objective of this article is to review the current evidence in etiology, clinical manifestations, diagnosis, and management alternatives of MC.

Background The use of artificial intelligence (AI) algorithms for the diagnosis of skin diseases has shown promise in experimental settings but has not been yet tested in real‐life conditions. Objective To assess the diagnostic performance and potential clinical utility of a 174‐multiclass AI algorithm in a real‐life telemedicine setting. Methods Prospective, diagnostic accuracy study including consecutive patients who submitted images for teledermatology evaluation. The treating dermatologist chose a single image to upload to a web application during teleconsultation. A follow‐up reader study including nine healthcare providers (3 dermatologists, 3 dermatology residents and 3 general practitioners) was performed. Results A total of 340 cases from 281 patients met study inclusion criteria. The mean (SD) age of patients was 33.7 (17.5) years; 63% (n = 177) were female. Exposure to the AI algorithm results was considered useful in 11.8% of visits (n = 40) and the teledermatologist correctly modified the real‐time diagnosis in 0.6% (n = 2) of cases. The overall top‐1 accuracy of the algorithm (41.2%) was lower than that of the dermatologists (60.1%), residents (57.8%) and general practitioners (49.3%) (all comparisons P < 0.05, in the reader study). When the analysis was limited to the diagnoses on which the algorithm had been explicitly trained, the balanced top‐1 accuracy of the algorithm (47.6%) was comparable to the dermatologists (49.7%) and residents (47.7%) but superior to the general practitioners (39.7%; P = 0.049). Algorithm performance was associated with patient skin type and image quality. Conclusions A 174‐disease class AI algorithm appears to be a promising tool in the triage and evaluation of lesions with patient‐taken photographs via telemedicine.

effectiveness of methotrexate in the management of localised scleroderma (morphea) based on an ultrasound activity score.

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dren. 1 Its aetiology is unknown, but it has been considered a dermal hypersensitivity reaction associated with viral infections (Echovirus, Coxsackie B, Epstein-Barr, Cytomegalovirus), drugs (including chemotherapy), foods, herbal medicine (deer horn, gingko nut, Kalopanax pictus), allergens and malignancies (acute lymphoblastic leukaemia). [2][3][4] Eruptive pseudoangiomatosis manifests as lesions consisting of small erythematous angioma-like papules with a perilesional pale halo, most commonly found in the extremities. 3 A prodrome of fever, sore throat or gastrointestinal symptoms is usually present. 1,3 It tends to resolve spontaneously in 1-2 weeks in children and 1-3 months in adults without sequelae; nevertheless, recurrences have been reported. 2 Less common in adults, the first cases were reported in 8 women and 1 man with an acute rash of numerous erythematous and telangiectatic papules on the face, limbs and trunk. 5 Unlike children, in adults, there is a predominance in women with no prodrome and a longer duration. 1 Our case was atypical, being a male patient with an axial distribution affecting the scalp, face and trunk with a duration of approximately 2 years.Routine laboratory test are normal. Occasionally, there is leukopenia and lymphocytosis. 3 Echovirus identification and positive serology for Epstein-Barr and Coxsackie virus along with prodrome, familial cases and a seasonal presentation during summer point to a viral aetiology. 1,4 However, most patients do not have a confirmed infectious aetiology. Histopathology shows dilated dermal blood vessels with plump endothelial cells and a mild to moderate lymphohystiocitic perivascular infiltrate. There is no evidence of vascular proliferation in the dermis or vasculitis. 2 Differential diagnosis includes viral exanthema, papular urticaria, multiple eruptive capillary hemangiomas, insect bites and leukocytoclastic vasculitis, among others. 1,3 No specific treatment is needed; however, pruritus can be managed with oral antihistamines and topical steroids, but this does not change the course of the disease. 2,3 A chronic and persistent evolution of 2 years and an axial distribution sparing the limbs make this an atypical case of eruptive pseudoangiomatosis.