The aim of this study was to evaluate the behavior of an anaerobic reactor of packed-bed and continuous flow, in relation to the biogas and methane production and the removal of organic load, from the wastewater of cassava starch extraction. For this purpose, were tested, in a reactor with a useful volume of 2.82 L and support mean of polypropylene filled with polyethylene foam, the organic loading rate (OLR) of 2.5, 5.0, 8.0 and 10.0 g L -1 d -1 . It was evaluated the removal of COD, the pH, the VA/TA ratio, the biogas and the methane production. It was concluded from this study that it is possible to produce biogas with methane percentages higher than 80% (maximum) and remove the organic load more than 90% under the tested conditions. In relation to stability, the reactor can be considered stable for the parameters, pH, the relationship between volatile acidity and total alkalinity and organic load removal. The best results in relation to the average volumetric biogas production (0.174 and 0.311 L g COD -1 ) were obtained for the higher organic loading rate (of 8 and 10 g L -1 d -1 , respectively) and the observed tendency is that with the increase of the organic loading rate, the specific biogas production will increase as well as the specific production of methane.
El reposicionamiento de fármacos como la derivatización química, que se han aplicado en los estudios de descubrimiento y diseño de fármacos contra el SARS-CoV-2, dependen del ciclo de vida del virus, las dianas moleculares identificadas y un diseño basado en su estructura e interacciones moleculares. Se realizó una revisión extensa en las bases de datos públicas e institucionales RSCB-Protein Data Bank, ZINC, NCBI (PubMed, PMC), PubChem, Science Direct e instituciones como CDC, NIH y revistas científicas especializadas sobre los avances en la búsqueda de nuevas moléculas contra el nuevo coronavirus basadas en estudios in silico, detectándose más de 40,000 publicaciones sobre SARS-CoV-2 y cerca de 200 relacionadas a dichos estudios, las consideradas más relevantes fueron analizadas e incluidas en este artículo. Su análisis evidencia el avance acelerado de las herramientas computacionales y fortaleza del diseño de fármacos asistido por computadora (in silico approach) para la generación de nuevas moléculas con posibilidad de ser activas contra COVID-19 y presenta las principales dianas moleculares sobre la que actúan estos agentes con potencial antiviral.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.