A method for the determination of serum lipase, using a one-hour hydrolysis period, is described. Studies of patients with acute pancreatitis have shown significant elevations of the serum lipase consistent with the clinical condition. Simultaneously performed analyses upon sera of patients for lipase and amylase have shown a close parallelism in the values obtained except in salivary gland disease in which there was elevation of serum amylase without increase in serum lipase. Studies designed to characterize the olive oil-splitting enzyme of serum have suggested that this enzyme is lipoprotein lipase.

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