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Galactic cosmic rays reach energies of at least a few Peta-electronvolts (1 PeV =1015 electron volts)1 . This implies our Galaxy contains PeV accelerators (PeVatrons), but all proposed models of Galactic cosmic-ray accelerators encounter non-trivial difficulties at exactly these energies 2 . Tens of Galactic accelerators capable of accelerating particle to tens of TeV (1 TeV =10 12 electron volts) energies were inferred from recent gamma-ray observations 3 . None of the currently known accelerators, however, not even the handful of shell-type supernova remnants commonly believed to supply most Galactic cosmic rays, have shown the characteristic tracers of PeV particles: power-law spectra of gamma rays extending without a cutoff or a spectral break to tens of TeV 4 . Here we report deep gamma-ray observations with arcminute angular resolution of the Galactic Centre regions, which show the expected tracer of the presence of PeV particles within the central 10 parsec of the Galaxy. We argue that the supermassive black hole Sagittarius A* is linked to this PeVatron. Sagittarius A* went through active phases in the past, as demonstrated by X-ray outbursts 5 and an outflow from the Galactic Center 6 . Although its current rate of particle acceleration is not sufficient to provide a substantial contribution to Galactic cosmic rays, Sagittarius A* could have plausibly been more active over the last 10 6−7 years, and therefore should be considered as a viable alternative to supernova remnants as a source of PeV Galactic cosmic rays.The large photon statistics accumulated over the last 10 years of observations with the High Energy Stereoscopic System (H.E.S.S.), together with improvements in the methods of data analysis, allow for a deep study of the properties of the diffuse very-high-energy (VHE; more than 100 GeV) emission of the central molecular zone. This region surrounding the Galactic Centre contains predominantly molecular gas and extends (in projection) out to r∼250 pc at positive galactic longitudes and r∼150 pc at negative longitudes. The map of the central molecular zone as seen in VHE γ-rays (Fig. 1) shows a strong (although not linear; see below) correlation between the brightness distribution of VHE γ-rays and the locations of massive gas-rich complexes. This points towards a hadronic origin of the diffuse emission 7 , where the γ-rays result from the interactions of relativistic protons with the ambient gas. The second important mechanism of production of VHE γ-rays 3 is the inverse Compton scattering of electrons. However, the severe radiative losses suffered by multi-TeV electrons in the Galactic Centre region prevent them from propagating over scales comparable to the size of the central molecular zone, thus disfavouring a leptonic origin of the γ-rays (see discussion in Methods and Extended Data Figures 1 and 2). The location and the particle injection rate history of the cosmic-ray accelerator(s), responsible for the relativistic protons, determine the spatial distribution of these cosmic rays which...

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We have developed a top-down, rule-based mathematical model to explore the basic principles that coordinate mechanochemical events during animal cell migration, particularly the local-stimulation-global-inhibition model suggested originally for chemotaxis. Cells were modeled as a shape machine that protrudes or retracts in response to a combination of local protrusion and global retraction signals. Using an optimization algorithm to identify parameters that generate specific shapes and migration patterns, we show that the mechanism of local stimulation global inhibition can readily account for the behavior of Dictyostelium under a large collection of conditions. Within this collection, some parameters showed strong correlation, indicating that a normal phenotype may be maintained by complementation among functional modules. In addition, comparison of parameters for control and nocodazole-treated Dictyostelium identified the most prominent effect of microtubules as regulating the rates of retraction and protrusion signal decay, and the extent of global inhibition. Other changes in parameters can lead to profound transformations from amoeboid cells into cells mimicking keratocytes, neurons, or fibroblasts. Thus, a simple circuit of local stimulation-global inhibition can account for a wide range of cell behaviors. A similar top-down approach may be applied to other complex problems and combined with molecular manipulations to define specific protein functions.

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