The three‐component reaction of isocyanides 1, carbodiimides 2, and trimethylsilyl azide (3) occurs at room temperature, and the produced 1,5‐disubstituted 1H‐tetrazole derivatives 4 are formed in 81–98% yields (Scheme 1, Table). The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions are observed.

Synthesis of 1,5-Disubstituted 1H-Tetrazole Derivatives via a Three-Component Reaction of Carbodiimides, Isocyanides, and Trimethylsilyl Azide. -The mild and efficient synthesis of the title compounds (III) is presented including an easy work-up and without the need of any purification. -(KAZEMIZADEH*, A. R.; HAJALIAKBARI, N.; HAJIAN, R.; SHAJARI, N.; RAMAZANI, A.; Helv. Chim. Acta 95 (2012) 4, 594-597 ; Dep. Chem., Islamic Azad Univ., Zanjan, Iran; Eng.) -C. Gebhardt