Introduction: In the recent years, some publications (mainly from one group of authors) have dealt with the effectiveness of proton–boron fusion therapy (PBFT). This theory is based on the Q-value of three produced α particles in the reaction of protons with boron (11B). They claim that this reaction significantly increases the absorbed dose in the target volume. However, the current study would re-evaluate their method to show if PBFT is really effective. Methods and materials: A parallel 80-MeV proton beam was irradiated on a water medium in a cubic boron uptake region (BUR). The two-dimensional dose distribution and percentage depth dose of protons, alphas and all particles were calculated using tally F6 and mesh-tallies by Monte Carlo N Particle Transport code. Results: The results not only showed that the dose enhancement in BUR is neglectable but also the higher density of BUR in comparison with water led to decrement of dose in this region. Because of low cross section of boron for proton beam (<100 mb), the α particles’ dose is 1,000 times lower than the proton dose. Conclusions: The physical aspects and the simulation results did not show any effectiveness of the PBFT for proton therapy dose enhancement.

Aim: Electron, photon or proton beams are used in radiotherapy for cancer treatment while each one may be used depending on depth and the location of tumor and normal tissues around the treatment target as well as economic issues. Materials and Methods: In this research, dose distribution by proton was measured by film dosimetry in nasal cavity Plexiglas phantom and Monte Carlo simulation. Then the DVH of treatment target and the posterior of treatment target of different beams were compared. The energies of electron, photon and proton were 9 MeV, 6 MV, and maximum 65 MeV, respectively. Due to a depth of 3.5 cm of CTV (Clinical Target Volume), Modulation Range was between 0-3.5 cm and SOBP (Spread-out Bragg Peak) was between 0-65 MeV. Results: Comparing the obtained DVH values, 95% dose coverage of target volume for electron, photon, proton and Photon-Electron beams were 88%, 98%, 98%, and 95%, respectively. However, doses above 40% that reached outside the target were 50%, 82%, 5%, and 44%, respectively. Conclusions: The results demonstrate the superiority of proton therapy in nasal cancer due to its better target volume coverage and the less amount of the dose reaching outside the target that is because of dose discharge in a small area and significant dose fall-off after Bragg peak.