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Summary Obesity is a chronic disease in which the abnormal or excessive accumulation of body fat leads to impaired health and increased risk of mortality and chronic health complications. Prevalence of obesity is rising rapidly in South and Southeast Asia, with potentially serious consequences for local economies, healthcare systems, and quality of life. Our group of obesity specialists from Bangladesh, Brunei Darussalam, India, Indonesia, Malaysia, Philippines, Singapore, Sri Lanka, Thailand, and Viet Nam undertook to develop consensus recommendations for management and care of adults and children with obesity in South and Southeast Asia. To this end, we identified and researched 12 clinical questions related to obesity. These questions address the optimal approaches for identifying and staging obesity, treatment (lifestyle, behavioral, pharmacologic, and surgical options) and maintenance of reduced weight, as well as issues related to weight stigma and patient engagement in the clinical setting. We achieved consensus on 42 clinical recommendations that address these questions. An algorithm describing obesity care is presented, keyed to the various consensus recommendations.

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High sensitivity C-reactive protein (hs-CRP) is an inflammatory marker recommended for risk stratification for individuals with high cardiovascular risk [8,9]. MetS is associated with high levels of hsCRP and linked to increased risk for CVD and diabetes [10,11].This study evaluated the associations between MetS, abnormal glucose tolerance and cardiovascular risk factors in Malaysian women with prior GDM. Currently, there is a paucity of similar data for the Malaysian population. Materials and Methods This project was approved by the Ethics and Research Review Committees of the institutions involved consistent with the national regulations. Subjects who were diagnosed to have had GDM (WHO criteria [12]) were identified 2-6 months after delivery. The inclusion criteria were women between the ages of 20-40 years with the presence of at-least one of the following three risk factors: 1.central obesity [described as a body mass index (BMI)>23 kg/m 2 , or waist circumference (WC)> 80 cm], 2. Dysglycaemia (Impaired glucose tolerance (IGT: 2-h plasma glucose ≥ 7.8 and <11.1 mmol/L [13]) and/

Twenty children (18 boys and 2 girls) with a proven or presumptive diagnosis of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency developed intravascular haemolysis following administration of antimalarials in 9, chloroquine and chloramphenicol in 1, chloroquine, chloramphenicol and aspirin in 1, chloramphenicol and aspirin in 3, and aspirin alone in 4. Eleven of these children developed acute renal insufficiency. All were managed with supportive care, including blood transfusion, forced diuresis and peritoneal dialysis wherever indicated. Only 16 children recovered completely. The occurrence of G-6-PD deficiency is being reported for the first time in Afghanistan.