The need of oxygen supplementation ⩾30% at day of life 30 may be a good screening tool for detecting late pulmonary hypertension in extremely low birth weight infants.

The accuracy of acanthosis nigrcans (AN) as a dermatological clinical marker to predict insulin resistance (IR) has not been well established in children. A cohort of obese Caucasian children was prospectively recruited. Demographic data, body mass index values, and laboratory data were compared for the presence or absence of AN. A total of 76 children participated. In all, 46 (60.5%) children had AN, and 34 (44.7%) children were positive for IR (>3.16); 25 (32.9%) children were positive for both AN and IR. Sensitivity, specificity, positive and negative predictive values, and accuracy level for AN to detect IR in the obese children who participated in this study were 73.5%, 50%, 54.3%, 70%, and 49%, respectively. The correlation between insulin and fasting glucose levels in AN-negative or AN-positive patients was low (R (2) = 13% to 17%). Acanthosis nigricans was only a surrogate marker for IR. It is concluded that IR should be examined in every obese West Virginian child irrespective of his or her AN status.

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We report a case of persistent bacteremia secondary to methicillin-resistant S. aureus (MRSA) in a preterm neonate successfully treated with daptomycin. Although the MRSA isolate was susceptible to vancomycin, there was no clinical or microbiologic response. Within 3 days of therapy with daptomycin, clinical improvement was noted, along with sterilization of blood cultures. Little data exist on neonatal pharmacokinetics of daptomycin. This report highlights the potential advantage that daptomycin offers in treating severe MRSA infections in neonates.