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Background: Perinatal asphyxia is a common neonatal problem and contributes significantly to neonatal morbidity and mortality. Only a third of deliveries in India are institutional and many asphyxiated babies are brought late to hospitals. In the absence of perinatal records, it is difficult to retrospectively diagnose perinatal asphyxia. There is a need to identify neonates with asphyxia who will be at high risk for hypoxic ischemic encephalopathy and multi-organ dysfunction. Subjects and Methods: The study was conducted on 60 neonates comprising the cases and 30 neonates comprising the controls meeting the inclusion and exclusion criteria. The blood samples for CK-MB and CRP, LDH was drawn at 24±2 and 72±2 hours of age respectively y and sent for analysis. Result: CK-MB value of >60 U/L was found to 43(71.7%) of cases, LDH >580U/L was found in 40(66.7%) of cases and CRP >1mg/dl was found in 5(8.3%) cases. Conclusion: CK-MB and LDH were found to be elevated in asphyxiated neonates compared to non asphyxiated neonates.

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