BackgroundMost empirical estimates of human elimination kinetics for persistent chemicals reflect apparent elimination half-lives that represent the aggregated effect of intrinsic elimination, ongoing exposure, and changes in body weight. However, estimates of intrinsic elimination at background levels are required for risk assessments for the general population.ObjectiveTo estimate intrinsic human elimination half-lives at background levels for nine polychlorinated biphenyl (PCB) congeners, we used a novel approach based on population data.MethodsWe used a population pharmacokinetic model to interpret two sets of congener-specific cross-sectional age–concentration biomonitoring data of PCB concentrations measured in lipid and blood samples that were collected from 229 individuals in 1990 and 2003. Our method is novel because it exploits information about changes in concentration in the human population along two dimensions: age and calendar time.ResultsOur approach extracted information about both elimination kinetics and exposure trends from biomonitoring data. The longest intrinsic human elimination half-lives estimated in this study are 15.5 years for PCB‐170, 14.4 years for PCB‐153, and 11.5 years for PCB‐180.ConclusionsOur results are further evidence that a maximum intrinsic elimination half-life for persistent chemicals such as PCBs exists and is approximately 10–15 years. A clear conceptual distinction between apparent and intrinsic half-lives is required to reduce the uncertainty in elimination half-lives of persistent chemicals. The method presented here estimates intrinsic elimination half-lives and the exposure trends of persistent pollutants using cross-sectional data available from a large and growing number of biomonitoring programs.

aBstraCt. the purpose of this study was to explore community perspectives on the most important ways that climate change is affecting the health of northern peoples. the study was conducted in Iqaluit, Nunavut, using a participatory action approach and the photovoice research method. Participants identified themes and patterns in the data and developed a visual model of the relationships between the themes identified. Five themes emerged from the data: the direct impacts of climate change on the health of individuals and communities, the transition from past climates to future climates, necessary adaptation to the changing climate in the North, the call to action (individual, regional, and national), and reflection on the past and changing knowledge systems. a climate change and health model was developed to illustrate the relationships between the themes. Participants in this study conceptualized health and climate change broadly. Participants believed that by engaging in a process of ongoing reflection, and by continually incorporating new knowledge and experiences into traditional knowledge systems, communities may be better able to adapt and cope with the challenges to health posed by climate change.Key words: Inuit, northern communities, Nunavut, climate change, health, action, participatory research rÉsuMÉ. l'objectif de cette étude consistait à explorer diverses perspectives communautaires quant aux manières les plus importantes dont le changement climatique a des incidences sur la santé des gens du Nord. l'étude a été réalisée à Iqaluit, au Nunavut, au moyen d'une méthode d'action et de recherche participative faisant appel à la « photovoice ». les participants ont déterminé les thèmes de même que les tendances caractérisant les données, puis ont abouti à un modèle visuel pour établir des relations entre les thèmes ainsi déterminés. les données ont donné lieu à la formulation de cinq thèmes, soit les incidences directes du changement climatique sur la santé des gens et des collectivités; la transition des anciens climats aux nouveaux climats; l'adaptation nécessaire au climat changeant dans le Nord; un appel à l'action (individuel, régional et national); et une réflexion sur les systèmes de savoir du passé qui sont en pleine évolution. Ensuite, un modèle de changement climatique et de santé a été élaboré dans le but d'illustrer les liens existant entre les divers thèmes. les participants à cette étude ont conceptualisé le changement climatique et ses incidences sur la santé à grande échelle. Ils croyaient qu'en s'adonnant à un processus de réflexion continue et qu'en intégrant constamment de nouvelles connaissances et expériences aux systèmes de savoir traditionnel, les collectivités pourraient être mieux placées pour s'adapter et relever les défis posés par le changement climatique en matière de santé.Mots clés : Inuit, collectivités du Nord, Nunavut, changement climatique, santé, action, recherche participative traduit pour la revue Arctic par Nicole Giguère.

Background: Human milk and blood are monitored to detect time trends of persistent organic pollutants (POPs) in humans. It is current practice to use log-linear regression to fit time series of averaged cross-sectional biomonitoring data, here referred to as cross-sectional trend data (CSTD). oBjective: The goals of our study are to clarify the interpretation of half-lives derived from fitting exponential functions to declining CSTD and to provide a method of estimating human elimination half-lives from CSTD collected in a postban situation. Methods: We developed a multi-individual pharmacokinetic model framework and present analytical solutions for a postban period. For this case, the framework quantitatively describes the relationships among the half-life for reduction of body burdens of POPs derived from CSTD, the half-life describing decline in daily intake, and the half-life of elimination from the human body. results: The half-life derived from exponential fitting of CSTD collected under postban conditions describes the exposure trend and is independent of human elimination kinetics. We use a case study of DDT (dichlorodiphenyltrichloroethane) to show that CSTD can be combined with exposure data obtained from total diet studies to estimate elimination kinetics of POPs for humans under background exposure conditions. conclusions: CSTD provide quantitative information about trends in human exposure and can be combined with exposure studies to estimate elimination kinetics. The full utility of these data has not been exploited so far. An efficient and informative monitoring strategy for banned POPs in humans would coordinate sampling of consistent sets of CSTD from young adults with total diet studies. key words: biomonitoring, DDT, exposure science, modeling, persistent organic pollutants.

The Southern Ocean (SO) carbon sink has strengthened substantially since the year 2000, following a decade of a weakening trend. However, the surface ocean pCO 2 data underlying this trend reversal are sparse, requiring a substantial amount of extrapolation to map the data. Here we use nine different pCO 2 mapping products to investigate the SO trends and their sensitivity to the mapping procedure. We find a robust temporal coherence for the entire SO, with eight of the nine products agreeing on the sign of the decadal trends, that is, a weakening CO 2 sink trend in the 1990s (on average 0.22 ± 0.24 Pg C yr −1 decade −1), and a strengthening sink trend during the 2000s (−0.35 ± 0.23 Pg C yr −1 decade −1). Spatially, the multiproduct mean reveals rather uniform trends, but the confidence is limited, given the small number of statistically significant trends from the individual products, particularly during the data-sparse 1990-1999 period. Plain Language Summary The Southern Ocean plays an important role in regulating Earth's climate as it takes up a substantial amount of carbon dioxide from the atmosphere, thereby limiting the effect of global warming. However, this part of the global ocean is also the least well observed and observational data are sparse. Therefore, to study Southern Ocean carbon uptake, data interpolation methods are used to estimate the variability of the carbon uptake from the few existing observations. This poses the question on how reliable these estimates are. The Surface Ocean CO 2 Mapping intercomparison project aims to do exactly that, that is, test how reliable current estimates are by comparing results from different methods. Here we compare the results from nine data interpolation methods in the Southern Ocean from 1990 to 2010 and find a broad and encouraging agreement regarding decadal carbon uptake signals, whereas a spatially more refined analysis reveals much less agreement locally, illustrating the need to continue the measurement effort in the Southern Ocean.

BackgroundPeople who live in dwellings treated with indoor residual spraying (IRS) of DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] for disease–vector control in the tropics and indigenous populations in the Arctic who comsume marine mammals experience high nonoccupational exposure to DDT. Although the use of DDT in IRS is rising, the resulting nonoccupational exposure is poorly characterized.ObjectivesWe have provided a comparative assessment of exposure to DDT and its metabolites in the general population of the tropical and northern regions and in highly exposed populations in these regions.MethodsWe compiled > 600 average or median DDT concentrations from the peer-reviewed literature, representing > 23,000 individual measurements in humans, food, air, soil, and dust. We use Monte Carlo sampling of distributions based on these data to estimate distributions of population- and route-specific uptake. We evaluate our exposure estimates by comparing them with biomonitoring data.ResultsDDT concentrations are highest in people living in IRS-treated houses and lowest in the northern general population, differing by a factor of about 60. Inuits and the general population in the tropics have similar concentrations. Inhalation exposure explains most of the difference in concentration between the highly exposed and the general population in the Tropics. Calculated exposure levels are consistent with human biomonitoring data.ConclusionsNonoccupational inhalation exposure is a relevant exposure pathway for people living in homes treated by IRS of DDT. Continued monitoring of time trends and DDE to DDT ratios in the Tropics and in the North is needed to identify a possible slowdown in concentration decline and the influence of ongoing DDT use.