Nondestructive SR-based µCT and nano-CT methods have been designed for 3D quantification and morphometric analysis of ultrastructural phenotypes within murine cortical bone, namely the canal network and the osteocyte lacunar system. Results in two different mouse strains, C57BL/6J-Ghrhr lit /J and C3.B6-Ghrhr lit /J, showed that the cannular and lacunar morphometry and their bone mechanics were fundamentally different. Introduction:To describe the different aspects of bone quality, we followed a hierarchical approach and assessed bone tissue properties in different regimens of spatial resolution, beginning at the organ level and going down to cellular dimensions. For these purposes, we developed different synchrotron radiation (SR)-based CT methods to assess ultrastructural phenotypes of murine bone. Materials and Methods:The femoral mid-diaphyses of 12 C57BL/6J-Ghrhr

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