While Transmission Control Protocol (TCP) works well with a low bit error rate (BER), the performance of TCP degrades significantly if the BER rises above a certain level. A study of the performance of TCP with high BER is required for the efficient design and deployment of such systems. In this paper, we address the problem of TCP performance in high BERs and analyze the issues by investigating the effect of BERs on system performance. We consider TCP Reno in our study to explore the system performance using extensive analysis of simulation and modeling. In the analysis, we consider the amount of datagram sent and retransmitted, mean throughput, link-layer overhead, TCP window size, FTP download response time, packet dropping and retransmission, and the TCP congestion avoidance mechanism. We validate simulation results by setting up a virtualized testbed using Linux hosts and a Linux router. The results obtained show that TCP throughput degrades significantly and eventually collapses at the packet drop probability of 10% (BER = 10−5). The FTP download response time is about 32 times longer than that of a perfect channel (no packet dropping). We found that TCP Reno cannot handle such a high BER to operate in wireless environments effectively. Finally, we provide recommendations for network researchers and engineers confronted with the challenge of operating TCP over noisy channels.