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suggest a decreasing trend in expression with obesity, with CYP2C9 being statistically significant (one-way ANOVA, P<0.001). Morbidly obese samples showed to be always the lowest in protein expression. The exception was CYP2E1 where protein expression increased with obesity. Since P450 protein expression generally decreases in obesity, this may also lead to lower enzyme activity and clearance. Globally, obese patients require more medical care and doses of medication than healthy individuals, rendering them prone to adverse drug reactions. Ultimately, understanding the relationship between obesity and hepatic detoxification can improve medical and dietary interventions to prevent morbidity and mortality in the obese population. None.