This research aims to describe the feasibility of blended learning, improvement of metacognitive skills, learning outcomes, as well as students' responses to Web-based Schoology blended learning with a scientific approach to the reaction rate material. The research used a pre-experimental design, namely One Group Pretest-Postest Design. The research was conducted in class XI IPA 3 SMAN 1 Gurah with 36 students without control’s class. The data collection techniques are used observation, test, and questionnaire. The data analysis methods used percentage, mean, paired t-test, and N-Gain test. The results showed that 1) Web-based Schoology blended learning was carried out very well criteria of 99.25%, 2) Metacognitive skills with Web-based Schoology blended learning got 0,534 improvement skills with good category. 3) Student learning outcomes also experienced completeness of 61,11% which states that the use of Web-based Schoology blended learning was good to improve learning outcomes 4) The response of students to the use of Web-based Schoology blended learning as a learning innovation using technology is considered good with 75% of students' responses. Generally, the Web-based Schoology blended learning was effective in improving students's metacognitive skills.