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This paper is a conceptual discussion of the construct of employee commitment identifying its antecedents in an organisational context. While the paper is of general interest to human resource management (HRM), it arose as part of a study on the commitment of academic staff in universities in Uganda. The paper suggests a framework for studying employee commitment, and proposes 21 hypotheses for future research basing on a review of recent literature. Each hypothesis suggests an antecedent. The antecedents are grouped into three categories, namely; HRM practices, organisational and personal characteristics. In terms of HRM practices, it is hypothesised that recruitment, selection, performance appraisal, promotion, participation, remuneration, job design, job security and grievances handling are antecedents of employee commitment. In regard to organisational characteristics, it is hypothesised that organisational structure, leadership styles, employee relationships and organisational support are antecedents of employ commitment. With personal characteristics, it is hypothesised that age, gender, educational level, marital status, job experience, job position and self-efficacy are antecedents of employee commitment. Gaps in the studies reviewed are identified.Keywords: Employee Commitment; HRM Practices

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Cyclophosphamide (CPA) containing chemotherapy regimen is the standard of care for breast cancer treatment in sub-Saharan Africa. Wide inter-individual variations in pharmacokinetics (PK) of cyclophosphamide (CPA) influence the efficacy and toxicity of CPA containing chemotherapy. Data on the pharmacokinetics (PK) profile of CPA and its covariates among black African patients is lacking. We investigated population pharmacokinetic/pharmacogenetic/pharmacodynamic (PK-PG-PD) of CPA in Ethiopian breast cancer patients. During the first cycle of CPA-based chemotherapy, the population PK parameters for CPA were determined in 267 breast cancer patients. Absolute neutrophil count was recorded at baseline and day 20 post-CPA administration. A population PK and covariate model analysis was performed using non-linear mixed effects modeling. Semi-mechanistic and empiric drug response models were explored to describe the relationship between the area under concentration-time curve (AUC), and neutrophil toxicity. One compartment model better described CPA PK with population clearance and apparent volume of distribution (V D) of 5.41 L/h and 46.5 L, respectively. Inter-patient variability in CPA clearance was 54.5%. Patients carrying CYP3A5*3 or *6 alleles had lower elimination rate constant and longer half-life compared to wild type carriers. CYP2C9 *2 or *3 carriers were associated with increased clearance of CPA. Patients who received 500 mg/m 2 based CPA regimen were associated with a 32.3% lower than average clearance and 37.1% lower than average V D compared to patients who received 600 mg/m 2. A 0.1 m 2 unit increase in body surface area (BSA) was associated with a 5.6% increment in V D. The mean V D (33.5 L) in underweight group (BMI < 18.5 kg/m 2) was significantly lower compared to those of overweight (48.1 L) or