• In studies conducted from 1991 to 2003, between 0.5% and 5.0% of the population used antisecretory medications on a long-term basis and were identified using a variety of definitions ranging from 1 repeated prescription over 12 months to continuous therapy for periods ranging from 4 to greater than 12 months. What is already known about this subject Analysis of Nonformulary Use of PPIs and Excess Drug Cost in a Veterans Affairs PopulationAdewale B. Ajumobi, MD, MBA, FACP; Ronald Vuong, BS; and Hycienth Ahaneku, MBBS, MPH ABSTRACT BACKGROUND: In the Veterans Affairs (VA) health care system, a formularybased approach without beneficiary cost-share incentives is used to limit the pharmacy cost of proton pump inhibitors (PPIs). However, the effectiveness of this approach in reducing the cost of PPIs is unknown.

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