Mollanol A is the first isolated member of the mollane-type grayanoids which possesses an unprecedented C-nor-D-homograyanane carbon skeleton and an 5,8-epoxide. Due to its transcriptional activation effects on the Xbp1 upstream promoters in different cell types, it has a potential therapeutic effect on inflammatory bowel disease. Here we report the first total synthesis of mollanol A, which constitutes a 15-step synthesis from commercially available materials via a convergent strategy. The synthesis involves an InCl3-catalyzed Conia-ene cyclization reaction to construct the bicyclo[3.2.1]­octane moiety and a vinylogous aldol reaction/intramolecular oxa-Michael addition sequence to rapidly assemble the oxa-bicyclo[3.2.1] core.

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This paper presents a Debris Flow Disaster Faster-than-early Forecast System (DFS) with wireless sensor networks. Debris flows carrying saturated solid materials in water flowing downslope often cause severe damage to the lives and properties in their path. Faster-than-early or faster-than-real-time forecasts are imperative to save lives and reduce damage. This paper presents a novel multi-sensor networks for monitoring debris flows. The main idea is to let these sensors drift with the debris flow, to collect flow information as they move along, and to transmit the collected data to base stations in real time. The Raw data are sent to the cloud processing center from the base station. And the processed data and the video of the debris flow are display on the remote PC. The design of the system address many challenging issues, including cost, deployment efforts, and fast reaction.