A photo-triggered self-catalyzed fluoroalkylation/cyclization of quinazolinones containing unactivated alkenes with various fluoroalkyl bromides has been developed.

A novel and green strategy for the synthesis of acylated quinazolinone derivatives via photo-induced decarboxylative cascade radical acylation/cyclization of quinazolinone bearing unactivated alkenes has been developed. The protocol provides a...

A visible-light-induced radical tandem cyclization/arylation between 2-amino-1, 4-naphthoquinone and N-allyl-2bromo-2,2-difluoroacetamides has been developed without an external photocatalyst. The transformation could be carried out at room temperature and gave a variety of C-3-functionalized 2-amino-1,4-naphthoquinone derivatives in moderate to excellent yields. Moreover, mechanistic studies revealed that the reaction is driven by the formation of an electron donor−acceptor (EDA) complex.

A mild, external photocatalyst-and additive-free protocol for photo-induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl-substituted quinazolinones with a broad substrate scope. More importantly, chlorinated alkanes were also compatible with this transformation.

A mild and efficient aerobic double Friedel-Crafts reaction of glycine derivatives with anilines has been developed with the assist of a photocatalytic system involving inexpensive Eosin Y as a photocatalyst. Under the optimized conditions, a range of N-arylglycine derivatives underwent this oxidative coupling reaction smoothly to give the desired diarylmethane derivatives with high para-regioselectivities in moderate to excellent yields. Moreover, mechanistic studies revealed that this transformation followed a radical-mediated pathway. This strategy featured mild conditions, operational simplicity, wide substrate scope and good functional group tolerance. Results and DiscussionTo begin our study, we chose glycine ester 1 a and N,Ndimethylaniline 2 a as model substrates to explore and optimize [a] J.