No abstract

DADS-induced G2/M arrest of MGC803 cells involves activation of p38 MAP kinase pathways. Decreased Cdc25C protein expression by p38 MAPK played a crucial role in G2/M arrest after treatment with DADS.

These results suggested that H pylori infection might play a certain role in the early stage of carcinogenesis of human gastric mucosa epithelia.

Vacuum residue is utilized by a process involving the residue cracking and coke gasification regeneration. In this process, vacuum residue is first converted into the products of light olefins and light oils by catalytic cracking, and then the cracking-generated coke is gasified into H2-rich syngas by using a bifunctional base catalyst. Their cracking gasification effects of vacuum residue are studied in a dual fluidized bed reactor. The results show that the solid base catalysts could enhance light olefin yield (have high olefinicity) and inhibit the formation of coke in comparison with silica sand and a hydrothermal treatment zeolite catalyst (FCC catalyst). Furthermore, the catalyst prepared at a CaO/Al2O3 molar ratio of 12:7 displayed a better cracking effect than the one produced at the molar ratio of 1:1. The effects of the reaction temperature and the catalyst-to-oil ratio on the distribution of cracking liquid from vacuum residue solid base cracking are discussed. The results showed that the heavy oil conversion of more than 93.0%, the light oil yield of about 81.0 wt %, the coke of ca. 5.2 wt %, and the C2–C3 olefinicity of higher than 53.0% are achieved by cracking at 700 °C with a catalyst-to-oil ratio of 7.0. The coke over solid base catalyst is well gasified at 800 °C in an atmosphere of steam–oxygen. The content of H2 is about 55.5 vol % and with the CH4 content of less than 0.2 vol % in comparison with 36.6 and 2.4 vol % over the FCC catalyst, respectively. The cracking effects of solid base catalysts are stable via a few cycles process, although a decrease in catalytic effect is observed.

The cell-specific information of transcriptional regulation on microRNAs (miRNAs) is crucial to the precise understanding of gene regulations in various physiological and pathological processes existed in different tissues and cell types. The database, mirTrans, provides comprehensive information about cell-specific transcription of miRNAs including the transcriptional start sites (TSSs) of miRNAs, transcription factor (TF) to miRNA regulations and miRNA promoter sequences. mirTrans also maps the experimental H3K4me3 and DHS (DNase-I hypersensitive site) marks within miRNA promoters and expressed sequence tags (ESTs) within transcribed regions. The current version of database covers 35 259 TSSs and over 2.3 million TF-miRNA regulations for 1513 miRNAs in a total of 54 human cell lines. These cell lines span most of the biological systems, including circulatory system, digestive system and nervous system. Information for both the intragenic miRNAs and intergenic miRNAs is offered. Particularly, the quality of miRNA TSSs and TF-miRNA regulations is evaluated by literature curation. 23 447 TSS records and 2148 TF-miRNA regulations are supported by special experiments as a result of literature curation. EST coverage is also used to evaluate the accuracy of miRNA TSSs. Interface of mirTrans is friendly designed and convenient to make downloads (http://mcube.nju.edu.cn/jwang/lab/soft/mirtrans/ or http://120.27.239.192/mirtrans/).