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The evolution of micro-strain and crystallographic texture of each phase of α+β Ti-6Al-4V titanium alloy generated during tensile deformation has been estimated numerically and then compared with the experimental results. It has been carried out based on the Crystal Plasticity Finite Element Model (CPFEM) simulation of the stress-strain curve till the uniform elongation for the equiaxed microstructure is generated synthetically. The synthetic microstructure of Ti-6Al-4V has been developed using the microstructure feature parameters (such as grain size, phase fraction, and grain orientation). The polycrystal stress-strain behaviour for the same has been simulated using the representative orientation distribution function data obtained from the electron backscatter diffraction (EBSD) scans. The present investigation discusses the mechanism of strain-partitioning during uniform elongation using CPFEM simulation in conjunction with EBSD-based experimental misorientation data to rationalize our observation.