BACKGROUND Pruritus is the primary clinical symptom of ICP. It may considerably impair the patient's quality of life causing sleep deprivation, psychological suffering and even suicidal thoughts. Pruritus is most severe in the evening, with a predilection for the palms of the hands and soles of the feet, and is not associated with any specific skin lesions. The main biochemical alterations are elevations of serum bile acids and aminotransferase activities. We wanted to study the outcome of pregnancy complicated by obstetric cholestasis in terms of maternal and foetal outcome. METHODS This is a prospective study done over a period of 18 months in 80 booked antenatal patients who complained of pruritus during their pregnancy. They were followed, and maternal and perinatal outcomes recorded. Appropriate statistical analysis was used for result. RESULTS Incidence of obstetric cholestasis in our hospital was 5%. Majority of the patients were primigravida (60%) and presented at gestational age between 32-36 weeks. Maternal morbidities are due to sleep disturbance (68.75%), dyslipidaemia (48.75%), deranged coagulation profile (22.5%), PPH (8.75%), increased operative interference (57.5%) and PROM (23.75%). Perinatal outcomes were MSL (23.75%), prematurity (25%), stillbirth (2.5%), NICU admission (18.75%), foetal distress (20%) and LBW (18.75%). Maximum number of patients were delivered between 37-38 weeks. CONCLUSIONS Active and timely intervention is needed to avoid unnecessary and early intervention and prevent the risk of prematurity.

Introduction: Increased body weight is a major epidemic for a developed country, and is also expanding to developing countries. It is measured as the body mass index (BMI). Control of body weight gain, where weight gain in adequate proportion is indicated, is a major challenge before, during, and after pregnancy. Aim:To find out whether the increased value of BMI as measured at 20 to 24 weeks of gestation can be used to predict the development of preeclampsia.Objective: To study the role of increased value of BMI in development of preeclampsia in normal pregnancies. Materials and methods:A case-control retrospective study was conducted on pregnant women who attended the antenatal clinic of Bokaro General Hospital, Jharkhand, India. About 220 pregnant women, who attended the antenatal clinic, in 20 to 24 weeks of gestation, were included after proper written consent for study.Results: About 220 patients were included in our study, who attended the antenatal clinic between 20th and 24th weeks of pregnancy. In our study, the maximum proportion of participants' BMI ranges between 22 to 24 and 24 to 26 kg/m 2 . In our study, we found with increase of BMI value, the percentage of preeclampsia development increases. Conclusion:In view of our results, counseling about body weight and its management should be known to the women before, during, and after pregnancy.

AFI are abnormal. STUDY DESIGN: prospective study carried out over 100 confirmed IUGR cases. MATERIALS AND METHODS: The IUGR cases were identified first by screening with SFH then confirmation with fetal abdominal circumference by USG at 32 weeks. All the cases were initially monitored with MBPP and BPP and color Doppler of Umbilical and MCA were performed in cases with abnormal MBPP having a non reactive NST. RESULTS: The incidence of IUGR was 3.86% in present study. The MBPP proved to be an effective tool for initial monitoring of IUGR cases with high specificity of 70.83%. The BPP and PI indices of Umbilical and middle cerebral arteries had good correlation with perinatal outcome i.e. BPP with sensitivity and PPV of 92.3% and 85.71%, Umbilical artery PI with sensitivity of 69.23% & positive predictive value of 90% and MCA PI with high specificity of 83.33% and PPV of 93.33%. CONCLUSION: MBPP is an effective initial surveillance tool in IUGR cases. The Biophysical profile, umbilical artery Doppler and Middle Cerebral artery Doppler have good correlation with perinatal outcome but further guidelines are required to integrate these surveillance modalities with each other.