Background:The aim of this study was to evaluate the results of amblyopia screening in Ardabil Province in three examination levels by kindergarten teacher, optometrist, and ophthalmologist.Methods:In a cross-sectional study, the results of the national amblyopic prevention program in 2–6 years old children in Ardabil Province were investigated in 2012. The results pertained to the examinations of children participating in this research were collected in the national approved forms. The data were entered into the computer and were analyzed using statistical methods in SPSS 18.Results:Around 38,844 children (51.7%) out of 75173 with 2–6 years old qualified children participated in the screening program in Ardabil Province. In the first stage of screening, 1068 children (33.1%) are visually impaired in one eye and 2160 children (66.9%) are visually impaired in two eyes. In the second stage, the results related to the examinations by optometrists indicated that the prevalence of refractive errors, strabismus, and others were 70%, 27.8%, and 2.2%, respectively. Refractive errors problem was most prevalent in Ardabil city (72.6%).The prevalence of refractive errors, strabismus, and other reasons in amblyopic children was 51.3%, 23.9%, and 24.8%; respectively.Conclusions:The present investigation showed that coverage of amblyopia screening program was not enough in Ardabil Province. To increase the screening accuracy, standard instruments and examination room must be used; more optometrists must be involved in this program and increasing the validity of obtained results for future programming.
The progress of genetic engineering in the 1970s brought about a paradigm shift in genome editing technology. The clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) system is a flexible means to target and modify particular DNA sequences in the genome. Several applications of CRISPR/Cas9 are presently being studied in cancer biology and oncology to provide vigorous site-specific gene editing to enhance its biological and clinical uses. CRISPR's flexibility and ease of use have enabled the prompt achievement of almost any preferred alteration with greater efficiency and lower cost than preceding modalities. Also, CRISPR/Cas9 technology has recently been applied to improve the safety and efficacy of chimeric antigen receptor (CAR)-T cell therapies and defeat tumor cell resistance to conventional treatments such as chemotherapy and radiotherapy. The current review summarizes the application of CRISPR/Cas9 in cancer therapy. We also discuss the present obstacles and contemplate future possibilities in this context.
Introduction: Thalassemia is a disorder that affects beta globin gene production and the resultant need for erythrocyte transfusions puts the patient at risk for iron loading, especially cardiac iron loading. Cardiac complications are the most serious ones accompanied by morbidity and mortality. The most harm to the heart is caused by iron overload. Ferritin is generally associated with the amount of stored iron in the body. The aim of this study was to investigate the relationship between echocardiographic findings and serum ferritin level. Materials & Methods:107 patients with thalassemia major were enrolled in this prospective analytical study. Serum ferritin levels and echocardiographic findings (diastolic, systolic, pulmonary artery pressure, valvular dysfunctions) were assessed. The data were analyzed by spearman statistical test.Results: Serum ferritin levels of the thalassemia major patients in the study were 2419.13±1772.65 ng/ml. there wasn't any significant relationship between echocardiographic findings and serum ferritin level. Conclusion:Although our findings didn't support the association between ferritin level and echocardiographic data but we suggest serial cardiac assessment to prevent the effect of increasing iron on the heart.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.