Context There is increasing evidence that intra-uterine lipid metabolism influences the adiposity of the newborn and the first years thereafter. It remains unclear if these effects persist when these children are growing older. Objective This study examined the associations between maternal lipid blood levels during 13 th week of pregnancy and offspring’s adiposity, measured at age 11-12, and if these associations were moderated by the child’s sex. Methods Data were obtained from a community-based birth cohort, the Amsterdam Born Children and their Development (ABCD) study. At a median of 13 weeks’ gestation, non-fasting blood samples of triglycerides (TG), total cholesterol (TC), free fatty acids (FFA) and apolipoprotein B/apolipoprotein A1 ratio (ApoB/ApoA1) were measured. Offspring’s body mass index (BMI), subcutaneous fat (SCF), waist-to-height-ratio (WHtR) and fat percentage (fat%) were measured at age 11-12. Mothers with at-term born children were included (n=1,853). Multivariable linear regression analyses were performed to assess the associations between maternal lipids and each offspring’s adiposity outcome, separately. Sex differences were additionally evaluated. Results TG, TC, ApoB/ApoA1 and FFA were significantly positively associated with BMI, WHtR and fat% (adjusted for gestational age at blood sampling, child’s age, sex and sexual maturation). After additional adjustments for potential confounders and covariates, only TG remained significantly associated with WHtR (0.45, 95%CI: -0.007; 0.91). There were no associations between maternal lipids and SCF and no clear sex-specific results were found. Conclusion Overall, our results do not strongly support that maternal lipid profile during 13 th week of pregnancy has programming effects on adiposity in preadolescence.