Objective The purpose of this systematic review was to examine how emodiversity affects mental and physical health. Emodiversity has been described as an integral component of the human emotional ecosystem that can serve as a predictor for mental and physical health. Data Selection This review was conducted using the following databases: Taylor & Francis, Science Direct, Google Scholar, and ProQuest Central. Inclusion criteria consisted of peer-reviewed articles published in English between the years of 2011–2019. Keywords for the search included emodiversity, emotional diversity, emotion, neuroscience, physical health, and mental health. A total number of 20 articles were reviewed and 8 articles were retained. Data Synthesis Research indicated that lack of differentiated emotional experiences, specifically the continuity of negative emotional states, stimulates inflammatory responses that are associated with negative moods and traits, such as depression and anxiety. Furthermore, heightened systemic inflammation has been associated with poor health conditions, such as Type II Diabetes, insulin resistance, rheumatoid disease, and oxidative stress. On the other hand, the presence of differentiation in emotions may lead to adaptive coping and adjustment. Emodiversity is also considered a predictor of habits that may contribute positively to physical health, such as healthy diets, regular exercise, and refraining from smoking. Conclusion Articles reviewed suggest that emodiversity is a fundamental criterion for evaluating the human emotional ecosystem. Reviewed literature showed that the absence of emodiversity may be related to different mental health conditions and physical illnesses. Studies have shown that diverse emotional experiences are beneficial for mental and physical health.