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Rationale: Premature Coronary artery disease (PCAD) is one of the major cause of death in recent decades. The aim of this study was to evaluate the association of dietary patterns among Iranian patients with PCAD. Methods: In this study, 65 consecutive patients were assessed before their planned coronary angiography. They were interviewed to obtain the nutrients based on a validated food frequency questionnaire. Diet pattern were calculated in each dietary group. Data was analyzed by descriptive statistics. Results: A total of 65 patients, with a mean age of 51.05 years and a mean body mass index of 25.4 ± 4.2kg/m2. 49.2% of patients had high blood pressure and 29.2% had diabetes. Moreover, 35% of patients had hypertriglyceridemia and high LDL-C levels and 36.9%) were smoker. Thirteen patients with PCAD had more than three blood vessels occlusion on angiography (20%) and the rest did not. However,Consumption of Sugars, Soft drinks, hydrogenated fats, and milk was associated with higher PCAD risk.

Introduction: Several studies have shown that diabetes mellitus (DM) is a risk factor for in hospital mortality due to COVID-19. The aim of our study was to analyze if prior clinical characteristics among DM patients affected the risk of in hospital mortality compared with nondiabetic patients hospitalized with COVID-19. Material and Methods: The study was based on a retrospective, observational design and was conducted at two hospitals located in Albacete (Spain). All patients hospitalized with COVID-19 since the start of the pandemic until 7 July 2020 were included. Results: During the study period, 1468 patients were hospitalized due to COVID-19; 402 of them had DM prior to hospitalization. DM was associated with higher in hospital mortality (28.6% versus 17.5%) in the univariate analysis. But, in a multivariate logistic regression analysis, after adjusting for age, presence of hypertension, smoking, presence of COPD, ACEI, ARB, antiplatelet, or anticoagulant therapy, DM was not a significant risk factor for death. Patients with DM2 receiving insulin treatment had a higher risk of in hospital death than nondiabetic patients (OR 1.78 [1.13-2.81], p=0.0126) after age was considered. The age-associated relative risk was 1.06 (1.05-1.07, p<0.001) per year, whereas the relative risk associated with DM2 treated with insulin compared with no DM was 1.57 (1.11-2.23, p=0.0111) suggesting that DM2 treated with insulin entails a risk of in hospital COVID-19 death equivalent to being 9 years older. When previous logistic regression models included other variables related to personal history and prior nondiabetic treatments, the risks described showed no change. Conclusion: This study confirms that pre-admission need for insulin therapy before hospitalization in patients with DM2 are associated with higher in hospital mortality due to COVID-19 in a large sample of DM inpatients with COVID-19. Disclosure P. J. Pinés-corrales: None. M. Molina: None. L. García-blasco: None. R. Quilez toboso: None. M. Alcaraz: None. L. Vicente gutiérrez: None. G. Paterna mellinas: None. J. Calbo mayo: None. J. Alfaro-martínez: None.

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