Febrile seizures (FeS) are the most common problem in pediatric neurological practice. They are convulsive episodes during the course of febrile illness in the absence of epilepsy, severe hydroelectrolytic imbalance or neuroinfection. Its diagnosis is clinical and classified as simple and complex. Febrile status epilepticus occurs in approximately 5% of cases. It is convenient to teach parents how to act in a seizure and clarify that a FeS is not epilepsy, it is a benign process that usually does not leave neurological sequelae, and in which mortality is zero. In this clinical guide, we indicate risk factors for recurrence, management instructions for the first FeS, as well as criteria for hospital admission and treatment for prolonged seizures.

Approximately 65% of children with newly diagnosed epilepsy achieve sustained control of their epileptic seizures with the antiepileptic drug (AED) initially prescribed, and 15-20% require the combination of other AEDs. To begin treatment with an AED, basic aspects should be considered, such as the capacity for absorption, distribution, metabolism, and elimination of each AED. Treatment with an AED in pediatric patients, as for any age, must be personalized, but in these cases, the biological age and its degree of development are fundamental. Furthermore, the type of seizure, type of epileptic syndrome, comorbidity, in many cases the etiology, and even other aspects such as tolerability and availability of use must be considered. If adequate seizure control is not achieved, synergistic combinations could be used, making sure that adverse effects are not increased. Remember that a high percentage of patients initiate their epilepsy in the pediatric stage, which is why management in this age group is fundamental, and doses must always be calculated in relation to the weight of the patient.

Objective: To compare performance of children with attention deficit hyperactivity disorders-combined (ADHD-C) type with control children in multi-source interference task (MSIT) evaluated by means of error related negativity (ERN). Method: We studied 12 children with ADHD-C type with a median age of 7 years, control children were age-and gender-matched. Children performed MSIT and simultaneous recording of ERN. Results: We found no differences in MSIT parameters among groups. We found no differences in ERN variables between groups. We found a significant association of ERN amplitude with MSIT in children with ADHD-C type. Some correlation went in positive direction (frequency of hits and MSIT amplitude), and others in negative direction (frequency of errors and RT in MSIT). Conclusion: Children with ADHD-C type exhibited a significant association between ERN amplitude with MSIT. These results underline participation of a cingulofronto-parietal network and could help in the comprehension of pathophysiological mechanisms of ADHD.Keywords: attention deficit hyperactivity disorder, multi-source interference task, event related potentials, error-related negativity, cingulo-fronto-parietal network. RESUMENObjetivo: Comparar el rendimiento de un grupo de niños con trastorno por déficit de atención-hiperactividad de tipo combinado (TDAH-C), con niños controles, en la tarea de interferencia multi-fuente (TIMF), evaluado por la negatividad relacionada al error (NRE). Método: Estudiamos 12 niños con TDAH-C con una mediana de 7 años, los controles estuvieron pareados por edad y género. Los niños realizaron la TIMF con registros simultáneos de NRE. Resultados: No encontramos diferencias en los parámetros de la TIMF entre grupos. No encontramos diferencias en las variables de la NRE entre grupos. Encontramos asociaciones significativas entre la amplitud de la NRE en niños con TDAH-C. Una correlación fue en dirección positiva: (frecuencia de aciertos y amplitud de TIMF), y otras fueron en dirección negativa (frecuencia de errores y el tiempo de respuesta en la TIMF). Conclusión: Los niños con TDAH-C presentan una asociación significativa entre la amplitud de la NRE con la TIMF. Los resultados sugieren la participación de la red cíngulo-fronto-parietal y pueden ayudar en la comprensión de los mecanismos fisiopatológicos del TDAH-C.Palabras clave: trastorno por déficit de atención-hiperactividad, tarea de interferencia multi-fuente, potenciales relacionados a eventos cognoscitivos, negatividad relacionada al error, red cíngulo-fronto-parietal.Attention deficit-hyperactivity disorder (ADHD) is an alteration whose main symptoms are inattention, hyperactivity, and impulsivity 1 . Children with ADHD present difficulties in several areas, such as those related to school, home or different social environments that affect their Quality of Life (QoL) 2 . Children with ADHD present alterations in other domains, such as executive functions (EF) 3 . Children with ADHD can be classified in three groups as follows: predominantly

INTRODUCTION: Epilepsy is considered a health problem. 85% of patients are satisfactorily controlled with antiepileptic drugs (AEDs) and 15% have refractory seizures. The combination of omega 3 and omega 6 fatty acids (EquazenTM) can contribute to changes in ionic currents and to stabilization of neurotransmitter's function resulting in cell membrane equilibrium. These changes lead to potential seizure control. OBJECTIVE: To compare efficacy and safety in the treatment of refractory epilepsy with a supplement combining EPA, DHA (omega 3 fatty acids) and GLA (omega 6 fatty acids). METHODS: We reviewed patients from the Neurology Department of the Children's Hospital of Mexico who have refractory epilepsy, evaluating clinical characteristics of seizures, number of seizures and AEDs. 792 mg of EPA, DHA and GLA per day (6 capsules of EquazenTM) were administrated for four weeks in order to assess the frequency of seizures as well as tolerability and probable side effects. RESULTS: The study was conducted with a total of 13 patients with follow-up four weeks after the start of supplementation. We obtained a satisfactory clinical response with ≥ 80% decrease in the daily number of seizures in more than 60% of patient. The mean of number of seizures over all patients was reduced significantly from 26.61±37.2 to 5.92 daily. In addition a significant improvement in the neurocognitive capacity was observedin all patients. CONCLUSION: The co-adjuvant supplementation with EquazenTM may result in a reduction of the number of seizures in refractory epilepsy having in addition significant impact on neurocognitive aspects. To enhance the quality of life of epileptic patient supplementation with a specific combination of EPA, DHA and GLA should be reconsidered.