This article is part of an investigation carried out in Spain by the Spanish League of Education of public utility (2018) in which the difficulties, methodologies and good practices in Education for Health, within the educational field with young people in vulnerable situation are presented. A mixed, quantitative-qualitative methodology was applied in which 458 professionals from 97 Secondary Education centres were interviewed in 32 localities in five autonomous communities. One of the main findings of the research is the relationship established with certain variables and the curricular-transversal approach to health issues in schools: gender, age, position, subject taught and territory definitely influence this approach. Thus, teaching biology, physical education or ethics, occupying positions of orientation or direction, presenting an age higher than the average or being a woman is related to presenting a broader vision of health and making a curricular approach to it.