Aim To conduct a systematic review of the literature on biosafety with the use of lasers. Methods The systematic review of literature was performed using MEDLINE (PubMed), Science Direct and Web of Science databases. The electronic search strategy included terms in the Medical Subject Heading (MeSH) related to biosafety in dentistry and laser, forms of contamination with aerosols, as well as their synonyms. The selected keywords were “aerosol virus transmission dentistry,” “laser‐generated air contaminants,” “biosafety dentistry laser” combined with the terms AND/OR. Results A total of 1334 abstracts were reviewed, resulting in inclusion of 23 reviews. The dental surgeons are professionals with a high risk of contamination; high‐power lasers form aerosols that need to be controlled and low‐power lasers must be protected to minimize the risks of cross‐infection. Conclusion The biosafety of using lasers is important for professionals can be more oriented as to the correct use of this equipment. This study has the relevance of showing biosafety measures for the professional, staff and patients, as well as suggesting that more studies that are clinical should be conducted in this area.

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medical and dental treatment in the form of ozonized water and oxygen / ozone gas mixture and associated with photobiomodulation therapy. The evidence map was based on the 3iE evidence searched in the databases: LILACS, PubMed, EMBASE and Cochrane Library, seeking systematic and narrative reviews, analyzed in an excel characterization spreadsheet. Three independent literature reviewers screened the systematic review search output blinded at the software Rayyan. The full-text publications were screened against the specified inclusion criteria by thre independent reviewers; disagreements were resolved through discussion. Forty-two studies were found, 16 of which were systematic reviews and 26 narrative reviews, published between 2006 and 2021, with different levels of confidence. The intervention that most appeared in the literature was oral ozone therapy as a bacterial colony reduction and decontamination agent, with emphasis on topical oxygen-ozone gas mixtures, topical ozonized water. Oral ozone therapy can bring benefits to clinical practice and patients. The evidence map provides an easy visualization of valuable information for patients, health practitioners and managers, in order to promote evidence-based complementary therapies.

The systemic effects of lasers have been observed for a long time. Despite a huge amount of evidence, its foundations are still being systematically investigated with several scientific experiments. As the metabolism in animals is systemic by nature, it should come as no surprise that localized excitation of molecules leads to generalized reactions, which can contribute to the rehabilitation of many diseases. As a new area of research, clinical cases presentations generate evidence for more in-depth fundamental studies. In this work, we report some different clinical cases, demonstrating the value of photobiomodulation in systematic situations. A collection of cases where vascular systemic photobiomodulation were employed are presented and inflammatory markers area evaluated. All cases considered are known to have long treatment and difficult results. The results presented with vascular systemic photobiomodulation are relevant in the considered to improve quality of life, stimulus for its use in general and as a motivation for in-depth studies in the area.