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August, p. 371) that these can be the sole cause of the blisters. Most authors have noted that they do not occur necessarily over maximum pressure areas and the area marked by a query illustrates this well in the letter from Sir Herbert Seddon and Mr. A. J. D. Howse. The marked epidermal necrosis and more recently reported eccrine sweat gland necrosis3 with little dermal damage are not features of pressure sores. In view of this I think we should not forget that it may be that the drugs may cause damage to the skin because of a direct effect on epidermal metabolism and not simply because they produce coma.In summary, therefore, I think that a combination of coma, pressure, and certain drugs are all necessary before the type of blister we have been discussing develops.-I

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