Acceptance of amniocentesis in the Hispanic and African American population in our prenatal diagnostic center is significantly lower than what has previously been reported in the literature for Caucasians and reported in California statewide prenatal diagnostic center data for non-MS-AFP. There was a significant decline in amniocentesis acceptance from 1995 to 2001. Our incidence of fetal abnormalities was higher than reported in California statewide data.

This report describes a full‐term male infant with trisomy 22 due to an isochromosome 22. Prenatal diagnosis with amniotic fluid showed two cell lines, one with an isochromosome 22 and the other with a deleted isochromosome 22. Subsequent cytogenetic analyses of cord blood, umbilical cord tissue, and placenta revealed additional cell lines. A normal cell line was found in umbilical cord tissue and two of three placental sites. The newborn had numerous dysmorphic features and died within 48 hrs of birth. © 2003 Wiley‐Liss, Inc.

between isozymes (*) and when compared to ZnBG for HO-1 ( †). All other comparisons were significant. Of note, the I50's of CrMP and ZnPP for both isozymes were significantly different from that previously found in the rat. We conclude that there is a wide spectrum of inhibitory potency and a fair level of selectivity among Mps with the constitutive HO-2 being more susceptible to inhibition than HO-1. These findings should be considered when comparing studies of Mps performed in rat and mouse models and in developing selective inhibitors of HO-1 for therapeutic purposes.