Aims/IntroductionThe aim of the present study was to determine the effect of moderate aerobic exercise on cardiac autonomic function in type 2 diabetic patients.Materials and MethodsHeart rate variability of 20 patients with type 2 diabetes was assessed. Resting electrocardiogram for the heart rate variability analysis at spontaneous respiration was recorded for 5 min in the supine position before and after 6 months of supervised aerobic training given three times per week.ResultsIn time domain measures, the square root of the mean of the sum of the squares of differences between adjacent R-R intervals (RMSSD; 29.7 [26–34.5] vs 46.4 [29.8–52.2] ms, P = 0.023) and the percentage of consecutive RR intervals that differ by more than 50 ms (pNN50; 10.7 [5.5–12.7] vs 26.1 [6.6–37.2]%, P = 0.025] were significantly increased after exercise. In frequency domain measures, low frequency (62.4 [59.1–79.2] vs 37 [31.3–43.3] nu, P = 0.003) and low frequency/high frequency (1.67 [1.44–3.8] vs 0.58 [0.46–0.59]%, P = 0.009) were significantly decreased, whereas high frequency (95 [67–149] vs 229 [98–427] ms2, P = 0.006) and high frequency (37.6 [20.8–40.9] vs 63 [56.7–68.7] normalized units, P = 0.003) were significantly increased after exercise. In a Poincaré plot, standard deviation perpendicular to the line of the Poincaré plot (SD1; 21.3 [18.5–24.8]–33.1 [21.5–37.2] ms, P = 0.027) was significantly increased after exercise.ConclusionsThese data suggest that three times per week moderate intensity aerobic exercise for 6 months improves cardiac rhythm regulation as measured by heart rate variability in type 2 diabetic patients.

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Introduction: Global threat of increasing population has become a challenge to control. That's why Family planning is a strong matter of concern for most of the developing countries like Nepal. The first family planning service in Nepal was provided by Family Planning Association Nepal (FPAN) in 1959 to provide an Integrated Package of Essential Services (IPES) that includes comprehensive counseling; family planning and sexual health services; safe abortion services; HIV and AIDS and other sexually-transmitted infection (STI) services; gynecological, prenatal, and post-natal care; and GBV care. Several studies reflect that increment in population is directly related to the level of education, low family income, and lack of awareness, strong cultural beliefs and many more. Especially, village areas of Nepal are deprived of Family Planning services and measures due to lack of coverage and other facilities. Thus knowledge regarding Family planning and contraception needs to be accessed and hence a village in Chisapani, Banke district of Nepal was chosen for this study. Objectives: The overall objectives of our study were to access the knowledge regarding Family planning, to access the practise of Contraceptive measures and to find out the contraceptive prevalence rate (CPR) among community people of Chisapani village, Banke. Material and Method: A Cross-sectional descriptive study with population size of  410 community people was performed in Chisapani, Banke; starting from 18th  June to 2nd  September, 2018. A pre-tested questionnaire containing structural, semi-structural and open ended questions were made as data collection tool. All the people in this study were interviewed after receiving consent as an ethical clearance. Result: 393 out of 410 (i.e. 95.85%) people in our studyhave known about Family planning via Mass Media (75.82%). Only 70.48% people responded to have used any Contraceptive measure. Depo was found to be the most used measure (i.e. 54.87%). 42.43% people have heard about emergency contraceptive pills but only 20.68% among them have ever used it. Conclusion: Though 95.85% of the respondents of our study had known about Family Planning however only 70.48% people have been using any of the contraceptive measures. Emergency contraceptive pills were used by only 20.68% of the respondents.

Introduction: Substance use among medical students could impact on the conduct, safety and efficiency of future doctors. Despite serious medico legal, ethical and political ramifications, there is paucity of published article on the subject, especially from Nepal. Objective: We aimed to explore the patterns of substance abuse among a sample of Medical students from Nepalgunj Medical College. Materials and Methods: A cross-sectional survey of medical students from Nepalgunj Medical College was done using a brief questionnaire schedule to identify current and lifetime use of tobacco, alcohol, cannabis and abuse of other drugs. An operational definition of substance abuse was made, 28 % of students fell within that criterion. Results: Male substance abusers 81% exceeded female abusers 19%. Substances most commonly abused were alcohol 60%, minor tranquilizers 48%, and tobacco 35%, and only 11% abused cannabis. While most students were multidrug users, there was a low frequency of daily drug use. A general lifetime (occasional use) prevalence of substance use of 56% was found. Drugs consumed on a daily basis were alcohol 2% and tobacco 6%. The prevalence of drug use was highest among the fourth and final year students. Conclusion: The majority of students were occasional abusers; there was no evidence of physical dependence. This study provides a snapshot of the problem of substance use among medical students of Nepal. Further research is needed to study nationwide patterns of substance use among medical students, and to identify important determinants and reinforce preventive measures. Strategies need to be developed for supporting students with a substance use problem.

Natural killer (NK) cells play a crucial role in immunity, killing virally infected and cancerous cells. The balance of signals initiated upon engagement of activating and inhibitory NK receptors with cognate ligands determines killing or tolerance. Nevertheless, the molecular mechanisms regulating rapid NK cell discrimination between healthy and malignant cells in a heterogeneous tissue environment are incompletely understood. The SHP-1 tyrosine phosphatase is the central negative NK cell regulator that dephosphorylates key activating signaling proteins. Though the mechanism by which SHP-1 mediates NK cell inhibition has been partially elucidated, the pathways by which SHP-1 is itself regulated remain unclear. Here, we show that phosphorylation of SHP-1 in NK cells on the S591 residue by PKC-θ promotes the inhibited SHP-1 ‘folded’ state. Silencing PKC-θ maintains SHP-1 in the active conformation, reduces NK cell activation and cytotoxicity, and promotes tumor progression in vivo. This study reveals a molecular pathway that sustains the NK cell activation threshold through suppression of SHP-1 activity.