Background: Cardiovascular disease (CVD) is the leading cause of deaths worldwide. In 2017, CVD contributed to 13,503 deaths in Malaysia. The current approaches for CVD prediction are usually invasive and costly. Machine learning (ML) techniques allow an accurate prediction by utilizing the complex interactions among relevant risk factors. Results: This study presents a case–control study involving 60 participants from The Malaysian Cohort, which is a prospective population-based project. Five parameters, namely, the R–R interval and root mean square of successive differences extracted from electrocardiogram (ECG), systolic and diastolic blood pressures, and total cholesterol level, were statistically significant in predicting CVD. Six ML algorithms, namely, linear discriminant analysis, linear and quadratic support vector machines, decision tree, k-nearest neighbor, and artificial neural network (ANN), were evaluated to determine the most accurate classifier in predicting CVD risk. ANN, which achieved 90% specificity, 90% sensitivity, and 90% accuracy, demonstrated the highest prediction performance among the six algorithms. Conclusions: In summary, by utilizing ML techniques, ECG data can serve as a good parameter for CVD prediction among the Malaysian multiethnic population.

A Chronic Kidney Disease (CKD) monitoring system was proposed for early detection of cardiovascular disease (CVD) and anemia using Fuzzy Logic. To determine the heart rate and blood oxygen saturation, the proposed model was simulated using MATLAB and Simulink to handle ECG and PPG inputs. The Pan-Tompkins method was used to determine the heart rate, while the Takuo Aoyagi algorithm was used to assess blood oxygen saturation levels. The findings show that the ECG recorded using the CKD model has all of the characteristics of a typical ECG wave cycle, but with reduced signal degradation in the 0.8-1.3mV region. The heart rate signal processing yielded findings between 78 and 83 beats per minute is within the range of the supplied heart rate. Takuo Aoyagi's pulse oximeter simulation generated the same findings. For real-time verification, the proposed model was implemented in hardware using ESP8266 32-bit microcontroller with IoT integration via Wireless Fidelity for data storage and monitoring. In comparison with the Fuzzy Logic simulation done on MATLAB and Simulink, the CKD monitoring device has 100% accuracy in patient status detection. The CKD monitoring system has an overall accuracy of 99% in comparison with a commercial fingertip pulse oximeter.

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