Abstrak (156,8 ± 33,1 vs 116,03 ± 5,66) . Begitu pula dengan konsentrasi VEGF pada kelompok anaerobik konsentrasi tertinggi terjadi pada hari pertama (36,37 ± 2,35), sedangkan pada kelompok aerobik konsentrasi VEGF tertinggi terjadi pada hari ke-3 (40,66 ± 1,73). Terdapat korelasi antara konsentrasi HIF-1α dan konsentrasi VEGF jaringan dengan tingkat korelasi sedang (r = 0,59) pada kelompok aerobik dan korelasi yang kuat pada kelompok anaerobik (r = 0,69). Kesimpulan: Aktivitas fisik aerobik dan anaerobik mengakibatkan peningkatan konsentrasi HIF-1α dan VEGF AbstractBackground: Exercise increases the need for oxygen to generate ATP through oxidative phosphorylation. If the high energy demand during exercise is not balanced by sufficient oxygen supply, hypoxia occurs in skeletal muscle tissue leading to upregulation of hypoxia inducible factor-1α (HIF-1α). The activity of HIF-1α increases the expression of various genes in order to reduce the metabolic dependence on oxygen and to increase oxygen supply to the tissue, e.g., VEGF which plays a role in angiogenesis. In myocardium, it is unlcear whether exercise leads to hypoxia and whether HIF-1α and VEGF play a role in the mechanism of hypoxic adaptation. This study aimed to investigate the correlation of HIF-1α and VEGF in heart muscle tissue of rats during aerobic and anaerobic exercise.

Senam kaki merupakan latihan yang dilakukan bagi penderita Diabetes Melittus (DM) atau bukan penderita untuk mencegah terjadinya luka dan membantu melancarkan peredaran darah bagian kaki.Perawat sebagai salah satu tim kesehatan, selain berperan dalam memberikan edukasi kesehatan juga dapat berperan dalam membimbing penderita DM untuk melakukan senam kaki sampai dengan penderita dapat melakukan senam kaki secara mandiri. Kegiatan Pengabdian Masyarakat dengan judul ”Pelatihan Senam Kaki Pada Penderita Diabetes Mellitus Dalam Upaya Pencegahan Komplikasi Diabetes Pada Kaki (Diabetes Foot)” telah dilaksanakan.di desa Indralaya Mulya. Dari kegiatan ini dapat disimpulkan bahwa seluruh peserta (100%) mengetahui tujuan dilakukannya senam kaki, mengetahui manfaat senam kaki, mengetahui indikasi dan kontraindikasi senam kaki dan antusias, perhatian serta aktif selama kegiatan pelatihan senam kaki.

BACKGROUND: Memory function disorder is a major health problem in geriatric patients. Physical exercise has the potency to decrease the incidence of many degenerative and chronic health problem, related to cognitive deterioration (dementia). AIM: This research aimed to observe the effect of physical exercise in various doses and duration on memory function by analysing the role of Brain-Derived Neurotrophic Factor (BDNF) as a regulatory protein affected by exercise. METHODS: This was an analytical observational study with a cohort design. Thirty participants were included in each group, classified as exercise and non-exercise group. The exercise was in the form of jogging for at least fifteen minutes every day. The observation was done for sixty days. Cognitive function assessment was done by using the Mini-Mental State Examination (MMSE) questionnaire. Meanwhile, the BDNF level was assessed by ELISA. Statistical analysis was done using Independent T-test. RESULTS: Exercise group showed better MMSE score (28.56 ± 1.76), and a higher concentration of BDNF (235.34 ± 12.56 pg/mL), both were statistically significant. CONCLUSION: Physical exercise was able to maintain geriatric cognitive function performance by BDNF protein regulation.

Autonomic and cardiovascular changes were studied when neuromuscular blockade was antagonized in 96 dogs with one of eight anticholinesterase-antimuscarinic drug combinations. Neostigmine (50 or 100 micrograms/kg) was administered before or after atropine (40 micrograms/kg) or glycopyrrolate (10 micrograms/kg). The high dose of neostigmine (100 micrograms/kg) caused bradyarrhythmias, salivation, and signs of bronchosecretion when used with either antimuscarinic agent and irrespective of the administration sequence. The heart rate increased, but not significantly, when atropine was injected before either dose of neostigmine. This did not occur when this administration sequence was reversed. Arrhythmias and cardiovascular and autonomic changes did not occur when glycopyrrolate was injected before or after neostigmine at 50 micrograms/kg.

ABSTRACT Postpartum hemorrhage is bleeding that exceeds 500 ml after the baby is born in vaginal delivery and exceeds 1000 ml after abdominal labor before 6 weeks of delivery. However, even a smaller amount of blood loss is very dangerous especially in anemic pregnant women. The purpose of this study was to determine the description of anemia in maternal with the incidence of postpartum hemorrhage.  This research is a descriptive study with cross sectional design using secondary data from medical records for the period of January 1 to December 31 in 2018 taken from two hospitals representing type A hospitals and Type B Hospitals in Palembang, namely RSUP Dr.  Mohammad Hoesin and Siti Khodijah Islamic Hospital Palembang with a total sample of 176. Data analysis used univariate analysis of the variables descriptively to determine the appearance of anemia in the incidence of postpartum hemorrhage. The results showed that of 111 mothers who experienced anemia there were 53 (47.7%) who experienced postpartum hemorrhage while of 65 mothers who were not anemic 14 (21.5%) had postpartum hemorrhage. The conclusion of this study is the picture of anemia in pregnant women tends to experience postpartum hemorrhage. Therefore, the government's action in an effort to prevent anemia in pregnant women by providing iron tablet supplements still needs to be done by looking at the socioeconomic conditions and education levels of the Indonesian people which are still mostly included in the poor category especially in rural areas. Keyword : Anemia; Post Partum Hemorrhage    ABSTRAK Perdarahan postpartum merupakan perdarahan yang melebihi 500 ml setelah bayi lahir pada persalinan pervaginam dan melebihi 1000 ml setelah persalinan abdominal sebelum 6 minggu persalinan. Akan tetapi kehilangan darah dengan jumlah yang lebih kecilpun sangat berbahaya khususnya pada keadaan wanita hamil yang anemis. Tujuan penelitian ini untuk mengetahui gambaran anemia pada ibu bersalin dengan kejadian perdarahan postpartum. Penelitian ini adalah penelitian deskriptif dengan desain cross sectional dengan menggunakan data sekunder rekam medik periode 1 Januari s/d 31 Desember tahun 2018 yang diambil dari dua rumah sakit yang mewakili rumah sakit tipe A dan Rumah Sakit Tipe B yang ada di Kota Palembang yaitu RSUP Dr. Mohammad Hoesin dan Rumah Sakit Islam Siti Khodijah Palembang dengan total jumlah sampel sebanyak 176. Analisis data menggunakan univariat yaitu menganalisis variabel secara deskriptif untuk mengetahui gambaran anemia pada kejadian perdarahan postpartum. Hasil penelitian didapatkan bahwa dari 111 ibu yang mengalami anemia ada sebanyak 53 (47,7%) yang mengalami perdarahan postpartum sedangkan dari 65 ibu yang tidak anemia ada 14 (21,5%) mengalami perdarahan postpartum. Kesimpulan dari penelitian ini adalah gambaran anemia pada ibu hamil cendrung mengalami perdarahan postpartum. Oleh sebab itu tindakan pemerintah dalam upaya mecegah anemia pada ibu hamil dengan pemberian suplemen tablet besi tetap perlu dilakukan secara melihat kondisi sosial ekonomi dan tingkat pendidikan masyarakat Indonesia yang masih sebagian besar masih termasuk dalam kategori miskin terutama didaerah pedesaan. Kata Kunci : Anemia dan Perdarahan Postpartum