INTRODUCTION. COVID-19 is a highly transmissible and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Algeria was also affected by the COVID-19, it was considered the third most affected country in Africa. AIM. The main aim of the study was to identify risk factors and the impact of risk factors on the incidence SARS-CoV-2 infection and the clinical course of the COVID-19, through a behavioral survey on a representative sample of the people who have been previously diagnosed with COVID-19. MATERIALS AND METHODS. A partial cross-sectional study of 808 people from a population of both sexes, aged 1 to 90 years allowed the description of the epidemiological profile of patients in the city of Oum-El-Bouaghi in eastern Algeria. RESULTS. The results of the study shows that the SASR-CoV-2 infection appears to be very strongly related to social and biological factor. The relationship between different BMI classes and the pandemic is confirmed by a significant difference (p