Nutrigenomics is the study of gene expression or metabolic pathway depending on different food material. In recent year, nutrigenomics has gained special attention due to its great potentiality for treating chronic disease. In this review, we have emphasized the importance of nutrigenomics on human health and on animal farm, specially on pork and poultry industries. Types of food consumption are crucial factor for human health in term of specific nutrition related gene expression and this knowledge is important for preparation of personalized diet. Human genome project identified several polymorphic gene and few of them are involved in metabolic pathway. The present review demonstrated the metabolism related disease like lactose intolerance and phenylketoneuria which is occurred due to polymorphic nature of that particular gene. Due to high cost of raw material, feed efficiency in pork and poultry industries is a crucial factor. In several investigations, researchers have used different combination of food material to monitor the growth and health of pig and chicken but it needs more accuracy and better understanding. Though the food product development and field application technique has a long way to go, further development in the field of nutrigenomics will definitely show it's potentiality in the food market and the growth of individuals. A greater understanding of these mechanisms will lead us to a sustainable fisheries, more production and other aquaculture activities.