BackgroundPregnancy in women with type 1 diabetes mellitus (T1DM) is associated with an increased risk of congenital malformations, obstetric complications and neonatal morbidity. This study aims to investigate maternal, perinatal and neonatal outcomes of pregnancies in women with onset of T1DM less than 18 years of age.MethodsThis retrospective cohort study extracted data regarding prenatal, intrapartum and postnatal outcomes of pregnancies in women with onset of T1DM<18 years identified from the diabetes in pregnancy register at University Maternity Hospital Limerick, treated from July 1, 2007 to July 1, 2017.ResultsSeventeen women with onset of T1DM <18 years gave birth to 23 live infants during the period studied. 73.9% of pregnancies were unplanned. Only 21.7% of pregnancies took preconceptual folic acid. 60.9% of infants required treatment for hypoglycemia.ConclusionThe high prevalence of unplanned pregnancy and poor uptake of prepregnancy care must be improved on in order to improve outcomes for this high-risk group.

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Chagas disease (CD) is an under-diagnosed tropical disease that is increasingly being observed outside of Latin America. We describe the first 2 infants with congenital Chagas Disease (cCD) in Ireland. Clinicians in nonendemic countries need to be aware of the potential for cCD due to the migration of women from countries of high prevalence.

Background Intraventricular haemorrhage (IVH) is a significant cause of morbidity and mortality in premature infants. There is a well known correlation between IVH grade and neurodevelopmental outcome. However, to our knowledge, there are only a few studies taking into account the side of the lesion. Methods Data of 178 infants with grade III IVH with and without parenchymal involvement were retrospectively analysed. Diagnosis was based on cerebral ultrasound. 36% (n = 64) of neonates showed equal IVH severity on both brain sides, the remaining 64% (n = 114) had IVH severity which differed between the hemispheres (right > left, n = 53; left > right, n = 61).Neurodevelopmental outcome was evaluated at 2 years corrected age via Bayley Scales of Infant development II (BSID II). The data was corrected for influence of gestational age by multiple regression analyses. Results Mental Development Index (MDI) and Psychomotor Development Index (PDI) were compared between the groups and infants with a larger lesion within the right hemisphere showed statistically significant lower developmental scores at the age of two years (mean Background and aims To evaluate the growth of occipito-frontal circumference (OFC), length and weight, between birth and term equivalent age (TEA) of very preterm infants and to compare to somatometry of term-born control infants. Methods We assessed prospectively a cohort of infants born at ≤32 weeks gestation and term control newborns. Infants with cerebral abnormalities were excluded. Measurements of OFC, length and weight were performed at birth and TEA for preterm and at birth for term infants. Brain volume was estimated by a previously described ultrasonographic model (Graca A, Early Hum Dev 2013). Z-scores for somatometric variables were determined based on Fenton 2013 growth charts and z-scores for estimated brain volume were defined in controls. We used paired samples t-test to compare z-scores between birth and TEA for preterms and independent samples t-test to compare z-scores between preterm infants at TEA and controls. Results We assessed 128 infants (72 preterms and 56 controls). Weight and length z-scores decreased significantly between birth and TEA and were significantly inferior to controls, whereas OFC z-scores increased and were identical at TEA to controls (Figure). Estimated brain volume was nevertheless significantly inferior for preterm infants at TEA. Conclusion Recovery of OFC z-score of healthy very preterm infants at TEA does not reflect a brain sparing effect, since despite OFC growing in a opposite direction than weight and length, estimated brain volume is significantly lower than controls. Background and aims Acute kidney injury (AKI) is a common consequence of perinatal asphyxia (PA). Therapeutic hypothermia (TH) used for neuroprotection in hypoxic-ischaemic-encephalopathy (HIE) may also ameliorate kidney injury. AKI can be associated with more severe PA, but association with worse neurological outcome remains to be proven. We aim to evaluate the incidence of AKI ...