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Adipose tissue browning is a physiological process that increases energy expenditure and may combat against obesity and its related risk factors. Fibroblast growth factor 21 and Irisin, hormones affected by exercise that also affect adipose tissue browning, have not been widely studied with regards to exercise type and duration. This study compared the effect of high-intensity interval training (HIIT) and high-intensity resistance training (HIRT) on Irisin and fibroblast growth factor 21 (FGF21) in men living with overweight and obesity. After completing a training program three times weekly for eight weeks, participants’ serum levels of Irisin and FGF21 were significantly increased in the HIIT and HIRT groups compared to the control group (p<0.05). Additionally, body fat percentage and body weight in both training groups were significantly reduced in comparison with the control group (p<0.05). Thus, HIIT and HIRT programs may be used as a feasible modality to promote favourable changes in body composition and Irisin and FGF21, factors critical for browning white adipose tissue in men living with overweight and obesity.

1. Introduction ecreased muscle mass in older people is attributed to impaired skeletal muscle ability to respond to anabolic stimulation and to D increase the activity of proteolytic signaling pathways [1]. According to studies, low exercise intensities like 30% of 1-Repetition Maximum (1RM) to voluntary fatigue are effective in stimulating muscle protein synthesis and hypertrophy [2]. In other words, in fatigue conditions, increased activity of the motor unit leads to increased activity of highthreshold motor units that innervate type II fibers and in

Objective: The purpose of this study was to compare eight weeks of exposure to sunlight and Home-Based Pilates Training serum vitamin D, CCL20, and the body composition of women with multiple sclerosis. Materials and Methods: This study was a quasi-experimental study. Among women with Multiple sclerosis (with2-5EDSS), 44 were purposefully and voluntarily selected and randomly divided into three groups: Pilates at home) n=15), Pilates exposed to the sun (n=15) and control (n=14) were divided. The training program consisted of three sessions per week for eight weeks, consisting of two parts, Pilates training at home and Pilates training in the environment. An exercise program on the DVD was provided. The Serum vitamin D, CCL20 indices, and body composition of patients with MS were measured 48 hours before and after eight Pilates exercises at home and under sunlight. To analyze the data, analysis of covariance and Bonferroni post hoc test, SPSS software, and P≤ 0.05 significance level. Results: Comparing the results in the two stages showed that there was a significant difference between CCL20 (P= 0.001), serum vitamin D (P= 0.001), BMI (P= 0.001), weight (P= 0.001) and WHR (P= 0.001) indices of women with MS in the studied groups. These differences were only between the training groups and the control group. However, there was a significant difference in the CCL20 index and serum vitamin D between the two training groups (Respectively P= 0.037, P= 0.001). Conclusion: Patients with MS can improve their vitamin D level and weight-related and inflammatory indicators by using Pilates exercises exposed to sunlight and at home with minimal cost.