This study sought to understand the health risks of foodborne pathogens in fresh leafy vegetables that are grown and consumed locally in Yaounde, Cameroon. Through a survey, 200 respondents were recruited to relate possible food-related illnesses to leafy vegetable consumption. Additionally, a total of 168 vegetable samples consisting of six leafy vegetables and 15 irrigated water samples from five water sources were collected from farms and local markets for microbiological analysis. Using a high-fidelity DNA polymerase, five potential bacterial pathogens, namely, Shiga-toxin producing Escherichia coli (STEC), Campylobacter spp., Salmonella spp., Listeria monocytogenes and Yersinia enterocolitica were also examined. The mean counts of total viable count and total coliforms followed decreasing trends from vegetables obtained on the farms to the local markets, and these ranged from 4.98-8.74 log cfu/g and 1.77-7.42 log cfu/g respectively. All pathogens detected were of significant concern to public health showing high occurrence in some vegetables: STEC (20%) and Yersinia enterolitica (13%) in cabbage, Campylobacter spp. (21%) in lettuce, Listeria monocytogenes (15%) in African nightshade, and Salmonella spp. (15%) in amaranth. Importantly, 42% of respondents highlighted that they frequently got sick from eating leafy vegetables from the study area. These microbiological and qualitative results along with certain vegetable farming and vending practices (such as the use of untreated sewage water for crop irrigation, the sales of physically dirty, muddy, and unpackaged vegetables) indicated that foodborne diseases could be occurring among leafy vegetable-consuming populations in Cameroon.