Resilience was significantly associated with a range of mental health constructs in a sample of older adults with depression. Future clinical trials and dismantling studies may help determine whether interventions targeting grit, active coping, accommodative coping, and spirituality can increase resilience and help prevent and treat depression in older adults.

Objective: To examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period.Methods: We studied 21 children (16 M/5 F) with msTBI, assessed 2-5 months postinjury and again 13-19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure. At the first time point, half of the patients with TBI had significantly slower IHTT (TBI-slow-IHTT, n 5 11) and half were in the normal range (TBI-normal-IHTT, n 5 10). Results:The TBI-normal-IHTT group did not differ significantly from healthy controls, either in WM organization in the chronic phase or in the longitudinal trajectory of WM organization between the 2 evaluations. In contrast, the WM organization of the TBI-slow-IHTT group was significantly lower than in healthy controls across a large portion of the WM. Longitudinal analyses showed that the TBI-slow-IHTT group experienced a progressive decline between the 2 evaluations in WM organization throughout the brain. Conclusions:We present preliminary evidence suggesting a potential biomarker that identifies a subset of patients with impaired callosal organization in the first months postinjury who subsequently experience widespread continuing and progressive degeneration in the first year postinjury. Neurology ® 2017;88:1392-1399 GLOSSARY AutoMATE 5 automated multi-atlas tract extraction; CC 5 corpus callosum; DWI 5 diffusion-weighted MRI; ERP 5 eventrelated potential; FA 5 fractional anisotropy; IHTT 5 interhemispheric transfer time; IRB 5 institutional review board; MD 5 mean diffusivity; msTBI 5 moderate/severe traumatic brain injury; PICU 5 pediatric intensive care unit; RD 5 radial diffusivity; TBI 5 traumatic brain injury; UCLA 5 University of California, Los Angeles; WM 5 white matter. Traumatic brain injury (TBI) is associated with substantial mortality and morbidity in children. Demyelination of white matter (WM) that is commonly found post-TBI 1,2 can have adverse cognitive repercussions. 3,4 In children, this disruption to myelin is compounded, as the brain is still maturing, and myelination continues well beyond age 30. 5,6 With diffusion-weighted MRI (DWI), we can identify WM disruptions postinjury. Prior work has shown lower WM organization in TBI, 7,8 suggesting disrupted myelin. Interhemispheric transfer time (IHTT) is the time required for signals to traverse the cerebral hemispheres through the corpus callosum (CC). It is an index of callosal functional organization; longer IHTT indicates slower information transfer. Both children and adults show slower IHTT following TBI.9,10 We measured IHTT using visual event-related potentials (ERPs), throughFrom the Imaging Genetics Center

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Human epidemiological studies implicate exposure to infection during gestation in the etiology of neurodevelopmental disorders. Animal models of maternal immune activation (MIA) have identified the maternal immune response as the critical link between maternal infection and aberrant offspring brain and behavior development. Here we evaluate neurodevelopment of male rhesus monkeys (Macaca mulatta) born to MIA-treated dams (n = 14) injected with a modified form of the viral mimic polyinosinic:polycytidylic acid at the end of the first trimester. Control dams received saline injections at the same gestational time points (n = 10) or were untreated (n = 4). MIA-treated dams exhibited a strong immune response as indexed by transient increases in sickness behavior, temperature, and inflammatory cytokines. Although offspring born to control or MIA-treated dams did not differ on measures of physical growth and early developmental milestones, the MIA-treated animals exhibited subtle changes in cognitive development and deviated from species-typical brain growth trajectories. Longitudinal MRI revealed significant gray matter volume reductions in the prefrontal and frontal cortices of MIA-treated offspring at 6 months that persisted through the final time point at 45 months along with smaller frontal white matter volumes in MIA-treated animals at 36 and 45 months. These findings provide the first evidence of early postnatal changes in brain development in MIA-exposed nonhuman primates and establish a translationally relevant model system to explore the neurodevelopmental trajectory of risk associated with prenatal immune challenge from birth through late adolescence.

Structural integrity of major white matter pathways implicated in cognitive control and emotion regulation (i.e., connecting prefrontal cortex) was positively associated with the resilience factor "grit" in our sample of older adults with depression. Prospective studies are needed to determine the utility of the structural integrity of these pathways as a biomarker in predicting risk for depression and treatment response.