Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC,  Vol. 14 No. 2 December 2016, Page: 60-65

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Background: Reviewing the teaching program at regular intervals and modifications in the teaching methodologies with understanding perceptions and opinions of medical students regarding teaching learning may prove useful in improving the teaching of pharmacology. The objective of the current study was to compare the effectiveness and to assess perception of Problem based learning (PB) and lecturer based learning (LB) in conveying the medical facts in pharmacology. Methods: A questionnaire was distributed to the students and asked to score each individual statement regarding LBL and PBL. The median total scores and median with interquartile range of individual statements was calculated. A comparison between questions that support LBL or PBL was performed. Student t-test was employed to compare the mean scores of different groups. Result: Among of one hundred and thirty five (135) students, only one hundred and ten (110) student participated in this study. The individual median score was 37 when compared to possible total score of 55. The total score (mean ± standard deviation for question 4-7 related to LBL was 2.920±0.614 and that of the questions 8-11 related to PBL was 3.863 ±0.738. This difference found statistically significant (p<0.05) Conclusion: Students had more positive perception on PBL compared to the LBL. In PBL, Student analyses the problem through self-directed efforts, solves the given problem by applying knowledge and skills followed by group discussions in adequate infrastructure, trained faculty, well-equipped library and internet facility which is always superior to didactic lectures.