Lamotrigine is used in the management of seizures and bipolar disorder. Cutaneous adverse drug reactions (CADRs) including severe forms are not uncommon following lamotrigine. Existing data suggest that the risk for adverse events could be reduced by initiating the drug at a lower dose and going for a slow titration to therapeutic dose. Here, we report four cases of lamotrigine-induced CADR. Three of the four suffered from severe drug reactions and in none of them lamotrigine was administered according to recommended guidelines.

BackgroundThere are conflicting reports on the association between interface dermatitis and hepatic involvement in DRESS.MethodsA cross‐sectional analysis of the clinical and the histopathologic features of DRESS was performed to study the association between the histopathology of the skin rash and hepatic involvement.ResultsThe clinical and the histopathologic findings were evaluated in 40 cases of DRESS. Thirty patients (75%) had a hepatic involvement. Thirty (75%) biopsy specimens showed a combination of different inflammatory patterns. The interface dermatitis was noted in 24 specimens (60%). Twenty‐one patients with the interface dermatitis had a hepatic involvement (P = .04).ConclusionsThe skin rash of DRESS often shows the coexistence of different inflammatory patterns. The interface dermatitis showed a statistically significant association with the hepatic involvement in DRESS.

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