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Two of the best characterized coat proteins are Coat Protein (COP) I and clathrin associated with Adaptor Protein 2 (AP-2), for which no common component has been identified. A GTPase-activating protein (GAP) for ADP-Ribosylation Factor 1 (ARF1), ARFGAP1, is known to act as a component of the COPI complex. Here, we find that distinct regions of ARFGAP1 interact with AP-2 and coatomer (components of the COPI complex). Selectively disrupting the interaction of ARFGAP1 with either of these two coats leads to selective inhibition in the corresponding transport pathway. Elucidating how ARFGAP1 acts in endocytosis regulated by AP-2, we find mechanistic parallels to its elucidated roles in COPI transport, as both its GAP activity and its coat function contribute to promoting AP-2 transport.

The oily wastewater generated in the industrial field is adversely affecting the environment, while the current methods for oil–water separation are complex and costly. Therefore, it is significant to use low cost and environmentally friendly materials to prepare a smart responsive superhydrophobic coating for the effective separation of oil–water mixtures. In this paper, a fluorine-free copolymer with pH responsiveness was fabricated by a solution impregnation method, and it was compounded by silica nanoparticles/polydimethylsiloxane to prepare a superhydrophobic coating on the paper and cotton fabric. The prepared superhydrophobic coating remained in the superhydrophobic state after the alkali treatment, while it would be converted into the hydrophilic state after the acid treatment. Therefore, the pH-responsive superhydrophobic coating will be applied in controlled selective oil–water separation.

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High-performance flexible pressure sensors are critical to realizing electronic skin and wearable devices. It is the persistent pursuit of researchers to develop more sensitive flexible pressure sensors. Here, we propose a simple and effective strategy to fabricate flexible piezoresistive pressure sensors based on fragmented graphene aerogel (FGA)/polydimethylsiloxane (PDMS) sponges. Using FGA as a conductive filler and NaCl particles as a porogen and blending with PDMS, a composite material FGA@PDMS with a sponge structure was obtained. Then, the composite FGA@PDMS was dip-coated with FGA to achieve the FGA/FGA@PDMS sponge. Finally, the interdigitated electrode was printed as the bottom electrode by the screen-printing process to complete the preparation of the FGA/FGA@PDMS sensor. The results show that the fabricated flexible piezoresistive pressure sensor has higher sensitivity (0–10 kPa, 2235.84 kPa–1), good recovery, shorter response time (∼120 ms), and stable response under 1000 cycles of loading and unloading. Moreover, we investigated the applicability of the FGA/FGA@PDMS sensor as a wearable device and its application in practical sensing. Human motion detection such as arm bending, fingers, and soles of the feet shows that the sensor has good detection ability. The light-emitting-diode series circuit and the bluetooth-based wireless pressure sensor verification prototype system demonstrate the potential of the sensor for practical applications.