ResumoThe proportion between amount of vegetables immersed and volume of water used during the disinfection step of minimally processed vegetables (MPV) is a factor that can affect the efficacy of disinfection process and consequently the quality and safety of the final product. This study aimed at assessing the influence of proportion between amount of vegetables immersed and volume of water on inactivation of Salmonella during the disinfection step of minimally processed lettuce and carrot, mimicking practices employed by MPV processing plants in Sao Paulo, Brazil. Minimally processed lettuce or carrot (1 Kg) was spiked with Salmonella (6 log CFU/mL) through immersion in experimentally contaminated water (4 L at 25ºC) for 30 min, and then transferred to recipients containing water with organic chlorine (250 mg/L at 25ºC and pH 7.0). The volumes of water tested to disinfect 1 Kg of lettuce were 8, 16, 23 and 28 L, while for disinfection of 1 Kg of carrot were tested 1, 6 and 12 L of water. These values corresponded to the proportions employed by Brazilian processing plants during disinfection step of MPV. The disinfection of minimally processed lettuce caused a reduction of 1.8, 1.9, 1.9 and 2.0 log CFU/g 363

Goal: Discuss the impacts of the pathophysiological process of hyperandrogenism in menacme diagnosed with polycystic ovary syndrome (PCOS). Method: Narrative Bibliographic Review carried out in October and November 2022 in the Scielo and Pubmed databases. Of the 370 articles found, 11 studies were selected after applying the inclusion and exclusion criteria. Discussion: The clinical manifestations of PCOS such as ovulatory disorders, infertility, hirsutism, acne, and androgenic alopecia are configured as the pathophysiological impacts of androgenism. Hyperinsulinemia is a condition present in women diagnosed with PCOS and which contributes in different ways to androgen-dependent anovulation. It is believed that irregular menstrual cycles are indicative of anovulation, considered favorable for infertility associated with PCOS. Final Considerations: In view of the expressive influence of the patient's physical conditions, therapies aimed at changes in lifestyle constitute the first management of such a situation.

2018 AGRADECIMENTOSAo meu pai, Rubison Olivo, por sempre apoiar minhas decisões. Você é a minha maior inspiração, profissional e de vida. À minha mãe, Maria Zélia de Souza, por compreender minhas escolhas e por ter dedicado a maior parte da sua vida para que eu me tornasse a pessoa que sou hoje.Ao meu namorado, Gilberto Rodrigues, por estar sempre ao meu lado, pela paciência, ensinamentos e, principalmente, compreensão por todos os finais de semana que não pudemos estar juntos. À Profa. Bernadette D.G.M. Franco, pela oportunidade, aprendizagem, paciência e por ter confiado a mim a realização deste trabalho sob sua supervisão.