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LEBER'S disease, with its sudden onset in adolescence or early adult life, its rapid course, and puzzling mode of inheritance, has overshadowed other forms of inherited optic atrophy. The early literature contained many cases of "atypical" Leber's disease, but the continued emphasis on the established form, even in the monumental review by Bell (1931), hampered the emergence of other forms as separate clinical entities. Waardenburg (1913) drew attention to the incidence of consanguinity in reported pedigrees of infantile optic atrophy suggestive of the existence of a recessive autosomal form. Rather more evidence for a dominant autosomal type is suggested by several reports in the early literature, such as the cases

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